Atropine sulfate and 2-pyridine aldoxime methylchloride elicit stress-induced convulsions and lethality in mice and guinea pigs.
Drug Chem Toxicol
; 8(6): 431-49, 1985.
Article
en En
| MEDLINE
| ID: mdl-4092617
The present study demonstrates that dose combinations of atropine sulfate and 2-pyridine aldoxime methylchloride (2-PAM), which do not produce any overt toxic effects on the behavior of mice or guinea pigs in a stable environment, elicit clonic-tonic convulsions and death when the animals are physically stressed by cold water swimming. Phenoxybenzamine (1-6 mg/kg), diazepam (0.625 and 1.25 mg/kg) and pilocarpine (2.5 and 5 mg/kg) significantly decreased (or abolished) the occurrence of atropine and 2-PAM stressed-induced convulsions and/or lethality. In contrast, propranolol (20 mg/kg), was ineffective in preventing either convulsions or lethality. Changes in plasma glucose levels and internal body temperature did not appear to explain the precipitation of convulsions or ensuing death. These results suggest that during acute physical stress, relatively low doses of atropine and 2-PAM produce toxic and lethal effects due to the activation of alpha-adrenergic mechanisms along with a concomitant inactivation of cholinergic mechanisms.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Pralidoxima
/
Atropina
/
Convulsiones
/
Estrés Fisiológico
Límite:
Animals
Idioma:
En
Revista:
Drug Chem Toxicol
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Estados Unidos