Structural considerations for calcium ionophoresis by prostaglandins.
Biochem Pharmacol
; 34(21): 3831-6, 1985 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-4062958
The prostaglandins PGB2, PGE2 and PGF2 alpha were found to translocate calcium in a modified Pressman cell. At pH 7.40, PGB2 was more potent than PGE2 and than PGF2 alpha. When incorporated at a 1% molar ratio in liposomes made of cholesterol and different diacyl phosphatidyl choline, prostaglandins are able to mediate a slow calcium exchange diffusion. A significant prostaglandin-mediated calcium release that depends on the lipid matrix rigidity is observable at 37 degrees but not at 22 degrees. Conformational analysis of the complex formed by two molecules of prostaglandins and one calcium atom, either at a simulated membrane-water interface or in a simulated bulk lipid phase reveals rigid complexes with great distances between hydrophilic and hydrophobic gravity centres that predict low ionophoretic properties.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prostaglandinas
/
Calcio
/
Ionóforos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Biochem Pharmacol
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Reino Unido