[Changes in water metabolism in rats under the influence of naloxone: role of vasopressin]. / Modifications du métabolisme hydrique du rat sous l'influence de la naloxone: role de la vasopressine.
Biomed Pharmacother
; 39(2): 94-8, 1985.
Article
en Fr
| MEDLINE
| ID: mdl-4016220
The effect of naloxone (0.6 mg; 1.2 mg; 2.4 mg X kg-1) were compared in normal Long Evans (N) and Brattleboro (D.I.) conscious rats. Naloxone did not change the values of drinking, diuresis, food intake, blood pressure, Na+ and K+ urinary excretion measured during 24 hours. During the two hours following drug injection, naloxone (1.2 and 2.4 mg X kg-1) reduced diuresis in normal as well as in D.I. rats. Water drinking was only modified in D.I. rats: this effect was shown to be a consequence of antidiuresis. These results suggest that the antidiuretic properties of naloxone are independent of vasopressin secretion. They do not support in a role of opiate receptors on vasopressin secretion in normal hydrated animals.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Agua Corporal
/
Vasopresinas
/
Diabetes Insípida
/
Naloxona
Límite:
Animals
Idioma:
Fr
Revista:
Biomed Pharmacother
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Francia