Influence of splenectomy and the functional hyposplenism of coeliac disease on platelet count and volume.
Scand J Haematol
; 34(5): 425-8, 1985 May.
Article
en En
| MEDLINE
| ID: mdl-4012222
Platelet count and volume were measured in 84 splenectomised subjects, 142 patients with coeliac disease and 77 healthy subjects. An inverse, non-linear correlation between platelet count and volume was found in healthy subjects and coeliac patients, but was not present in splenectomised subjects who had higher platelet counts (P = 0.0001) and mean platelet volumes (P = 0.0001) than healthy subjects. Platelet counts correlated with splenic function in patients with coeliac disease and were higher in patients with severe hyposplenism than in normosplenic coeliacs (P = 0.0001). Splenic function did not influence the mean platelet volume (MPV) in coeliac disease but normosplenic coeliacs had higher MPV than normal subjects (P = 0.05). Serum iron and red cell folate were not correlated to MPV in coeliac disease. We conclude that splenic function effects platelet count and volume in non-coeliac subjects and platelet count in coeliac disease. However, other unidentified factor(s) influence the MPV in coeliac disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esplenectomía
/
Enfermedades del Bazo
/
Plaquetas
/
Enfermedad Celíaca
Tipo de estudio:
Etiology_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Scand J Haematol
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Dinamarca