Development, Use, and Validation of (Q)SARs for Predicting Genotoxicity and Carcinogenicity: Experiences from Italian National Institute of Health Activities.
Methods Mol Biol
; 2834: 231-247, 2025.
Article
en En
| MEDLINE
| ID: mdl-39312168
ABSTRACT
In silico approaches are now increasingly accepted in several areas of toxicology to rapidly assess chemical hazard without the need for animal testing. Among in silico tools, quantitative and qualitative structure-activity approaches ((Q)SARs) are the most typically applied methods to predict hazard in the absence of experimental data. This paper provides an overview of different protocols that can be applied while dealing with (Q)SARs in different scenarios, namely, (Q)SAR development, use, and validation. Examples of protocols adopted in the three scenarios are reported, derived from the authors' experience in working at the Predictive Toxicology unit of the Italian National Institute of Health, focusing on the endpoints of carcinogenicity and genotoxicity.The illustrated activities are in line with the Institute's mission, the main center of research, control, and technical-scientific advice on public health in Italy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Relación Estructura-Actividad Cuantitativa
Límite:
Animals
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2025
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Estados Unidos