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IgG-k/IgG-λ Para-Osseous Plasmacytoma Relapsed as Soft-Tissue Plasmacytoma with IgA-k Immunophenotype: A Case Report and Review of the Literature on Related Biochemical Aspects.
Fazio, Manlio; Sorbello, Chiara Maria Catena; Del Fabro, Vittorio; Romano, Alessandra; Cannizzaro, Maria Teresa; Parrinello, Nunziatina Laura; Esposito, Benedetta; Frazzetto, Sara; Elia, Federica; Di Raimondo, Francesco; Conticello, Concetta.
Afiliación
  • Fazio M; Post-Graduation School of Haematology, University of Catania, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.
  • Sorbello CMC; Division of Haematology and BMT, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.
  • Del Fabro V; Post-Graduation School of Haematology, University of Catania, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.
  • Romano A; Division of Haematology and BMT, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.
  • Cannizzaro MT; Division of Haematology and BMT, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.
  • Parrinello NL; Dipartimento di Specialità Medico-Chirurgiche, Dipartimento di Chirurgia Generale e Specialità Medico-Chirurgiche, Sezione di Ematologia, Università degli Studi di Catania, 95131 Catania, Italy.
  • Esposito B; Radiology via Santa Sofia 78 AOU Policlinico-"Vittorio Emanuele", 95123 Catania, Italy.
  • Frazzetto S; Division of Haematology and BMT, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.
  • Elia F; Post-Graduation School of Haematology, University of Catania, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.
  • Di Raimondo F; Division of Haematology and BMT, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.
  • Conticello C; Post-Graduation School of Haematology, University of Catania, A.O.U. 'Policlinico-San Marco', 95123 Catania, Italy.
Hematol Rep ; 16(3): 541-551, 2024 Aug 29.
Article en En | MEDLINE | ID: mdl-39311139
ABSTRACT
Neoplastic plasma cells (PCs) proliferation at anatomic sites dislocated from the bone marrow (BM) or their contiguous growth from osseous lesions that disrupt the cortical bone is termed extramedullary multiple myeloma (EMD). EMD still remains challenging from a therapeutic and biological perspective. Pathogenesis has not been completely clarified, and it is generally associated with high-risk cytogenetics (HRCAs). In order to emphasize the clinical and biochemical complexity of this disease, we have decided to describe the case of a patient affected by relapsed-refractory (RR) EMD, which presented as para-osseous plasmacytoma with a bi-phenotypical immunoglobulin (Ig) component and lately relapsed as soft-tissue plasmacytoma with a total immunophenotype switch. We have also hypothesized a correlation between Ig patterns and prognosis and suggested the possible inclusion of these biochemical features in the general risk assessment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Hematol Rep Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Hematol Rep Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza