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Evolving Horizons in Pediatric Leukemia: Novel Insights, Challenges, and the Journey Ahead.
Tito Rodriguez, Piere R; Mehta, Deepalee; Subhan, Muhammad; Yadav, Ratan Pal; Yousofzai, Bibi Sarah; Al-Najjar, Ebtesam H; Bibi, Ruqiya; Idries, Mohamed; Singh, Atinder; Adnan, Muhammad.
Afiliación
  • Tito Rodriguez PR; Medicine, Universidad Privada del Valle, La Paz, BOL.
  • Mehta D; Internal Medicine, Bharati Vidyapeeth Medical College, Sangli, Sangli, IND.
  • Subhan M; Medicine, Allama Iqbal Medical College, Jinnah Hospital, Lahore, PAK.
  • Yadav RP; Pediatrics, NRI Academy of Sciences, Guntur, IND.
  • Yousofzai BS; Obstetrics and Gynaecology, Be Team International Cure Hospital, Kabul, AFG.
  • Al-Najjar EH; Internal Medicine, Houston Methodist Hospital, Houston, USA.
  • Bibi R; Medicine, Allama Iqbal Medical College, Jinnah Hospital, Lahore, PAK.
  • Idries M; Biochemistry, St. George's University School of Medicine, St. George's, GRD.
  • Singh A; Medicine, World College of Medical Sciences and Research Hospital, Gurugram, IND.
  • Adnan M; Pediatrics, Lady Reading Hospital, Peshawar, PAK.
Cureus ; 16(8): e67480, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39310608
ABSTRACT
Pediatric leukemia, encompassing acute lymphoblastic leukemia (ALL) and acute myeloid leukemia, remains a formidable challenge despite significant treatment advancements. This review examines recent developments in immunotherapy, chemotherapy, and bone marrow transplantation for pediatric leukemia through a comprehensive analysis of recent literature, focusing on critical studies and clinical trials. Immunotherapy, including monoclonal antibodies, such as blinatumomab and inotuzumab ozogamicin, and chimeric antigen receptor T-cell therapies, such as tisagenlecleucel and brexucabtagene autoleucel, have demonstrated promising results in relapsed or refractory B-cell ALL (B-ALL), achieving notable remission rates with manageable side effects. Chemotherapy continues to be the primary treatment, utilizing multiphase regimens tailored to individual risk profiles. Bone marrow transplantation, especially allogeneic stem cell transplantation, offers potential cures for high-risk or relapsed cases, though it poses risks including graft-versus-host disease and infections. Despite these advancements, treatment resistance, toxicity, and accessibility persist. This review also discusses the long-term outcomes among pediatric leukemia survivors, focusing on late-onset side effects associated with treatments such as chemotherapy and bone marrow transplantation, encompassing secondary malignancies, organ dysfunction, and neurocognitive impacts. Ongoing research and clinical trials are crucial to refine these therapies, enhance their efficacy, and reduce adverse effects, ultimately improving young patients' survival and quality of life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos