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Radix Astragali and Its Representative Extracts for Diabetic Nephropathy: Efficacy and Molecular Mechanism.
Xue, Hui-Zhong; Chen, Yu; Wang, Shi-Dong; Yang, Yi-Meng; Cai, Lu-Qi; Zhao, Jin-Xi; Huang, Wei-Jun; Xiao, Yong-Hua.
Afiliación
  • Xue HZ; The First Clinical Medical School Beijing University of Chinese Medicine, Beijing, China 100700.
  • Chen Y; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, China 100700.
  • Wang SD; Section II of Endocrinology & Nephropathy Department Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, China 100700.
  • Yang YM; The First Clinical Medical School Beijing University of Chinese Medicine, Beijing, China 100700.
  • Cai LQ; The First Clinical Medical School Beijing University of Chinese Medicine, Beijing, China 100700.
  • Zhao JX; Section II of Endocrinology & Nephropathy Department Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, China 100700.
  • Huang WJ; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, China 100700.
  • Xiao YH; Section II of Endocrinology & Nephropathy Department Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, China 100700.
J Diabetes Res ; 2024: 5216113, 2024.
Article en En | MEDLINE | ID: mdl-39308629
ABSTRACT
Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus (DM). Radix Astragali (RA), a frequently used Chinese herbal medicine in the Leguminosae family, Astragalus genus, with its extracts, has been proven to be effective in DN treatment both in clinical practice and experimental studies. RA and its extracts can reduce proteinuria and improve renal function. They can improve histopathology changes including thickening of the glomerular basement membrane, mesangial cell proliferation, and injury of endothelial cells, podocytes, and renal tubule cells. The mechanisms mainly benefited from antioxidative stress which involves Nrf2/ARE signaling and the PPARγ-Klotho-FoxO1 axis; antiendoplasmic reticulum stress which involves PERK-ATF4-CHOP, PERK/eIF2α, and IRE1/XBP1 pathways; regulating autophagy which involves SIRT1/NF-κB signaling and AMPK signaling; anti-inflammation which involves IL33/ST2 and NF-κB signaling; and antifibrosis which involves TGF-ß1/Smads, MAPK (ERK), p38/MAPK, JNK/MAPK, Wnt/ß-catenin, and PI3K/AKT/mTOR signaling pathways. This review focuses on the clinical efficacy and the pharmacological mechanism of RA and its representative extracts on DN, and we further document the traditional uses of RA and probe into the TCM theoretical basis for its application in DN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Nefropatías Diabéticas Límite: Animals / Humans Idioma: En Revista: J Diabetes Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Nefropatías Diabéticas Límite: Animals / Humans Idioma: En Revista: J Diabetes Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido