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Evaluation of the systemic effect of bone formation marker released by endodontic calcium silicate-based sealers in local tissues, the bloodstream, and body organs.
De Azevedo Queiroz, Índia Olinta; de Mello, Wagner Garcez; Machado, Thiago; de Oliveira, Maria Carolina Guiotti; Vasconcelos, Bruno Carvalho; de Oliveira, Sandra Helena Penha; Duarte, Marco Antonio Hungaro.
Afiliación
  • De Azevedo Queiroz ÍO; Department of Dentistry, Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil. india.queiroz@ufsc.br.
  • de Mello WG; Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, USP, Bauru, São Paulo, Brazil. india.queiroz@ufsc.br.
  • Machado T; Department of Basic Science, Araçatuba Dental School, UNESP, Araçatuba, São Paulo, Brazil.
  • de Oliveira MCG; Department of Oral and Maxillofacial Surgery and Integrated Clinic, Araçatuba Dental School, UNESP, Araçatuba, São Paulo, Brazil.
  • Vasconcelos BC; Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, USP, Bauru, São Paulo, Brazil.
  • de Oliveira SHP; Department of Dentistry Campos Sobral, Federal University of Ceará, UFC, Sobral, Ceará, Brazil.
  • Duarte MAH; Department of Basic Science, Araçatuba Dental School, UNESP, Araçatuba, São Paulo, Brazil.
Odontology ; 2024 Sep 21.
Article en En | MEDLINE | ID: mdl-39305358
ABSTRACT
Calcium silicate-based sealers are bioactive materials that release ions when in contact with body fluids. Therefore, this study aims mapping/trace bone formation markers released by MTA Fillapex, BioRoot RCS, and experimental tricalcium silicate-based sealer (CEO) into subcutaneous tissues, bloodstream and body organs. Toward, polyethylene tubes filled with sealers were implanted into connective tissue of Wistar rats. On days 7, 15, 30, and 45 after implantation, blood samples were collected to measure calcium (Ca2+), phosphorus (P), and alkaline phosphatase (ALP) levels. Thereafter, the animals were killed, and the brain, liver, kidneys, and subcutaneous tissue were removed and processed to determine the concentrations of Ca2+ and P by ICP-OES. Similar Ca2+ levels were observed in subcutaneous tissue for all groups, although, at 45 days, it was identified a reduction in Ca2+ serum levels of CEO compared to those two other sealers and an increase in Ca2+ levels in the liver compared to those released by MTA Fillapex. In contrast, no trace of P was detected in any tissue; moreover, plasma P and ALP serum levels of MTA Fillapex were higher at day 30. Our findings showed that Ca2+ were identified in local tissues, bloodstream, and organs from all sealers. The up-regulation of bone marker levels promoted by sealers can modify body homeostasis and induce tissue damage. Besides, MTA Fillapex was associated with a raise of bone marker levels, suggesting a possible systemic effect. The sealer composition can affect not only the local repair process but also the systemic health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Odontology Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Odontology Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Japón