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Immune-mediated hemolytic anemia in a bottlenose dolphin: Case report and literature review.
Carmezim, Sofia; Rojo-Solis, Carlos; Valls, Monica; Alvaro, Teresa; Alvarez, Rocío; Marcos, Ricardo.
Afiliación
  • Carmezim S; Cytology and Hematology Diagnostic Services, Laboratory of Histology and Embryology, ICBAS-School of Medicine and Biomedical Sciences, University of Porto (U.Porto), Porto, Portugal.
  • Rojo-Solis C; Oceanogràfic Veterinary and Laboratory Service, Ciudad de las Artes y las Ciencias, Valencia, Spain.
  • Valls M; Oceanogràfic Veterinary and Laboratory Service, Ciudad de las Artes y las Ciencias, Valencia, Spain.
  • Alvaro T; Oceanogràfic Veterinary and Laboratory Service, Ciudad de las Artes y las Ciencias, Valencia, Spain.
  • Alvarez R; Servicio de Medicina Interna del Hospital Veterinario de Referencia Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain.
  • Marcos R; Cytology and Hematology Diagnostic Services, Laboratory of Histology and Embryology, ICBAS-School of Medicine and Biomedical Sciences, University of Porto (U.Porto), Porto, Portugal.
J Vet Diagn Invest ; : 10406387241276032, 2024 Sep 21.
Article en En | MEDLINE | ID: mdl-39305173
ABSTRACT
A 15-y-old captive-born female bottlenose dolphin (Tursiops truncatus) had slowly progressive lethargy, inappetence, and pallor of the oral mucosa. Serial hemograms and serum biochemistry analysis revealed hemolyzed plasma, gradually severe anemia with reticulocytosis, spherocytosis, pronounced neutrophilia with left shift and toxic change, and indirect hyperbilirubinemia. Urinalysis identified both hemoglobinuria and bilirubinuria. Hyperglobulinemia with polyclonal gammopathy was evident by protein electrophoresis, and the saline agglutination test was positive. Splenomegaly and hyperechogenic liver were also observed on ultrasound. These findings meet the diagnostic criteria established for immune-mediated hemolytic anemia (IMHA) in small animals, which is extremely rare in cetacean species, and, to our knowledge, has not been fully documented. Several potential triggers of a secondary IMHA were ruled out, including the most common cetacean virus, exposure to new drugs, and recent vaccination events. Following recommendations from companion animal medicine, immunosuppressive therapy was implemented and proved effective in this bottlenose dolphin; the CBC returned to normal after 3 mo of treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Vet Diagn Invest Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Vet Diagn Invest Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos