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Spatial proteomics: unveiling the multidimensional landscape of protein localization in human diseases.
Wu, Mengyao; Tao, Huihui; Xu, Tiantian; Zheng, Xuejia; Wen, Chunmei; Wang, Guoying; Peng, Yali; Dai, Yong.
Afiliación
  • Wu M; School of Medicine, Anhui University of Science & Technology, Huainan, China.
  • Tao H; School of Medicine, Anhui University of Science & Technology, Huainan, China. 475433093@qq.com.
  • Xu T; Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China. 475433093@qq.com.
  • Zheng X; Anhui Province Engineering Laboratory of Occupational Health and Safety, Huainan, China. 475433093@qq.com.
  • Wen C; School of Medicine, Anhui University of Science & Technology, Huainan, China.
  • Wang G; The First Hospital of Anhui University of Science and Technology, Huainan, China.
  • Peng Y; School of Medicine, Anhui University of Science & Technology, Huainan, China.
  • Dai Y; School of Medicine, Anhui University of Science & Technology, Huainan, China.
Proteome Sci ; 22(1): 7, 2024 Sep 20.
Article en En | MEDLINE | ID: mdl-39304896
ABSTRACT
Spatial proteomics is a multidimensional technique that studies the spatial distribution and function of proteins within cells or tissues across both spatial and temporal dimensions. This field multidimensionally reveals the complex structure of the human proteome, including the characteristics of protein spatial distribution, dynamic protein translocation, and protein interaction networks. Recently, as a crucial method for studying protein spatial localization, spatial proteomics has been applied in the clinical investigation of various diseases. This review summarizes the fundamental concepts and characteristics of tissue-level spatial proteomics, its research progress in common human diseases such as cancer, neurological disorders, cardiovascular diseases, autoimmune diseases, and anticipates its future development trends. The aim is to highlight the significant impact of spatial proteomics on understanding disease pathogenesis, advancing diagnostic methods, and developing potential therapeutic targets in clinical research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Proteome Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Proteome Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido