Your browser doesn't support javascript.
loading
Greater urinary calcium excretion is associated with diminished bone accrual in youth with type 1 diabetes.
Weber, David R; O'Brien, Kimberly O; Ballester, Lance; Rackovsky, Noya; Graulich, Bethany; Schwartz, George J.
Afiliación
  • Weber DR; Department of Pediatrics, The Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania.
  • O'Brien KO; Division of Nutritional Sciences, Cornell University.
  • Ballester L; Biostatistics and Data Management Core, The Children's Hospital of Philadelphia.
  • Rackovsky N; Department of Pediatrics, Golisano Children's Hospital, The University of Rochester School of Medicine and Dentistry.
  • Graulich B; Department of Pediatrics, Golisano Children's Hospital, The University of Rochester School of Medicine and Dentistry.
  • Schwartz GJ; Department of Pediatrics, Golisano Children's Hospital, The University of Rochester School of Medicine and Dentistry.
J Clin Endocrinol Metab ; 2024 Sep 20.
Article en En | MEDLINE | ID: mdl-39302657
ABSTRACT
CONTEXT The adverse skeletal effects of type 1 diabetes (T1D) include deficient bone accrual and lifelong increased fracture risk. The contributors to impaired bone accrual in people with T1D are incompletely understood.

OBJECTIVE:

To determine if urinary calcium excretion is associated with impaired bone accrual in youth with T1D and to characterize the contribution of glycemic control and markers of bone mineral metabolism to urinary calcium excretion.

DESIGN:

Observational study.

PARTICIPANTS:

50 participants with T1D aged 6-20 years completed a 12-month longitudinal study of bone accrual. A second cohort of 99 similarly aged participants with T1D completed cross-sectional 24-hr urine and blood collections. MAIN OUTCOME

MEASURE:

Whole body less head bone mineral content (WBLH BMC) velocity Z-score and fractional excretion of calcium (FeCa).

RESULTS:

Participants in the bone accrual cohort had lower WBLH BMC velocity compared to a healthy reference dataset (Z-score -0.3 ± 1.0, p=0.03). FeCa was negatively associated with WBLH BMC velocity Z-score, ρ= -0.47, p=0.001. In the urinary calcium excretion cohort, intact parathyroid hormone (ß= -0.4, p=0.01), beta c-telopeptide (ß=0.35, p=0.007), and either hemoglobin A1c (HbA1c, ß=0.08, p=0.03) or urine fractional glucose excretion (ß=0.07, p=0.03) were associated with FeCa in multivariable regression models that included known determinants of urinary calcium excretion.

CONCLUSIONS:

Urinary calcium excretion was negatively associated with bone accrual in this cohort of youth with T1D. Mechanistic studies are needed to determine if interventions to reduce urinary calcium excretion could increase bone accrual and reduce skeletal fragility in people with T1D.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos