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Global Processing Deficit in Amnestic Mild Cognitive Impairment.
Veronelli, Laura; Daini, Roberta; Mannino, Alice; Rossetti, Alessia; Gilardone, Giulia; Corbo, Massimo; Primativo, Silvia.
Afiliación
  • Veronelli L; Department of Psychology, University of Milano-Bicocca, Milan, Italy.
  • Daini R; Department of Neurorehabilitation Sciences, Casa di Cura IGEA, Milan, Italy.
  • Mannino A; Department of Psychology, University of Milano-Bicocca, Milan, Italy.
  • Rossetti A; Department of Neurorehabilitation Sciences, Casa di Cura IGEA, Milan, Italy.
  • Gilardone G; Department of Psychology, University of Milano-Bicocca, Milan, Italy.
  • Corbo M; Department of Psychology, University of Milano-Bicocca, Milan, Italy.
  • Primativo S; Department of Neurorehabilitation Sciences, Casa di Cura IGEA, Milan, Italy.
J Alzheimers Dis ; 2024 Sep 14.
Article en En | MEDLINE | ID: mdl-39302364
ABSTRACT

Background:

Visuo-perceptual and visuo-attentional disorders, such as global processing deficit and simultanagnosia, are not routinely investigated in prodromal forms of typical Alzheimer's disease, as amnestic mild cognitive impairment (MCI).

Objective:

This study evaluated global processing abilities through Navon's classical paradigm in individuals with amnestic MCI and investigated the related visuo-perceptual and attentional components involved in simultanagnosia.

Methods:

Sixteen consecutive patients with amnestic MCI (6 single-domain, 10 multiple-domain) and 16 matched controls were requested to identify global and local elements of hierarchical Navon letters, and to name large and small solid letters.

Results:

While correctly identifying solid letters, patients with multiple-domain amnestic MCI were less accurate in processing the global level of hierarchical stimuli compared to controls. Single-case analyses suggested that global processing may also be impaired in single-domain amnestic MCI. In addition, patients with pathological performance in the Navon task showed perceptual and/or visual focal attention deficits.

Conclusions:

Early dysfunction of holistic processing can be detected in amnestic MCI. Visuo-perceptual and/or visual focal attention mechanisms, which have been shown to be damaged in Posterior Cortical Atrophy patients with simultanagnosia, may be impaired in individuals with amnestic MCI. Investigation and identification of global processing deficits in MCI could contribute to early diagnosis and longitudinal monitoring of the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos