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Determinants of cerebral blood flow and arterial transit time in healthy older adults.
Feron, Jack; Segaert, Katrien; Rahman, Foyzul; Fosstveit, Sindre H; Joyce, Kelsey E; Gilani, Ahmed; Lohne-Seiler, Hilde; Berntsen, Sveinung; Mullinger, Karen J; Lucas, Samuel J E.
Afiliación
  • Feron J; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
  • Segaert K; Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
  • Rahman F; Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
  • Fosstveit SH; School of Psychology, University of Birmingham, Birmingham, UK.
  • Joyce KE; Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
  • Gilani A; School of Psychology, University of Birmingham, Birmingham, UK.
  • Lohne-Seiler H; College of Psychology, Birmingham City University, Birmingham, UK.
  • Berntsen S; Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway.
  • Mullinger KJ; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
  • Lucas SJE; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Aging (Albany NY) ; null2024 Sep 18.
Article en En | MEDLINE | ID: mdl-39302230
ABSTRACT
Cerebral blood flow (CBF) and arterial transit time (ATT), markers of brain vascular health, worsen with age. The primary aim of this cross-sectional study was to identify modifiable determinants of CBF and ATT in healthy older adults (n = 78, aged 60-81 years). Associations between cardiorespiratory fitness and CBF or ATT were of particular interest because the impact of cardiorespiratory fitness is not clear within existing literature. Secondly, this study assessed whether CBF or ATT relate to cognitive function in older adults. Multiple post-labelling delay pseudo-continuous arterial spin labelling estimated resting CBF and ATT in grey matter. Results from multiple linear regressions found higher BMI was associated with lower global CBF (ß = -0.35, P = 0.008) and a longer global ATT (ß = 0.30, P = 0.017), global ATT lengthened with increasing age (ß = 0.43, P = 0.004), and higher cardiorespiratory fitness was associated with longer ATT in parietal (ß = 0.44, P = 0.004) and occipital (ß = 0.45, P = 0.003) regions. Global or regional CBF or ATT were not associated with processing speed, working memory, or attention. In conclusion, preventing excessive weight gain may help attenuate age-related declines in brain vascular health. ATT may be more sensitive to age-related decline than CBF, and therefore useful for early detection and management of cerebrovascular impairment. Finally, cardiorespiratory fitness appears to have little effect on CBF but may induce longer ATT in specific regions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos