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The relationship between ethnicity and multiple sclerosis characteristics in the United Kingdom: A UK MS Register study.
Jacobs, Benjamin M; Schalk, Luisa; Tregaskis-Daniels, Emily; Tank, Pooja; Hoque, Sadid; Peter, Michelle; Tuite-Dalton, Katherine; Witts, James; Bove, Riley; Dobson, Ruth.
Afiliación
  • Jacobs BM; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK Department of Neurology, Royal London Hospital, London, UK.
  • Schalk L; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK.
  • Tregaskis-Daniels E; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK.
  • Tank P; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK.
  • Hoque S; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK.
  • Peter M; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK.
  • Tuite-Dalton K; UK MS Register, University of Swansea, Swansea, UK.
  • Witts J; UK MS Register, University of Swansea, Swansea, UK.
  • Bove R; UCSF Weill Institute for Neurosciences, UCSF, San Francisco, CA, USA.
  • Dobson R; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK Department of Neurology, Royal London Hospital, London, UK.
Mult Scler ; : 13524585241277018, 2024 Sep 20.
Article en En | MEDLINE | ID: mdl-39301820
ABSTRACT

BACKGROUND:

Previous studies have suggested differences in multiple sclerosis (MS) severity according to ethnicity.

METHODS:

Data were obtained from the UK MS Register, a prospective longitudinal cohort study of persons with MS. We examined the association between self-reported ethnic background and age at onset, symptom of onset and a variety of participant-reported severity measures. We used adjusted multivariable linear regression models to explore the association between ethnicity and impact of MS, and Cox proportional hazards models to assess disability progression.

RESULTS:

We analysed data from 17,314 people with MS, including participants from self-reported Black (n = 157) or South Asian (n = 230) ethnic backgrounds. Age at MS onset and diagnosis was lower in those of South Asian (median 30.0) and Black (median 33.0) ethnicity compared with White ethnicity (median 35.0). In participants with online MS severity measures available, we found no statistically significant evidence for an association between ethnic background and physical disability in MS in both cross-sectional and longitudinal analyses.

CONCLUSION:

We found no association between ethnic background and MS severity in a large, diverse UK cohort. These findings suggest that other factors, such as socioeconomic status and structural inequalities, may explain previous findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido