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Multiomics and single-cell sequencings reveal the specific biological characteristics of low Ki-67 triple-negative breast cancer.
Han, Boyue; Han, Xiangchen; Luo, Hong; Nasir, Javaria; Chen, Chao; Shao, Zhiming; Ling, Hong; Hu, Xin.
Afiliación
  • Han B; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery Fudan University Shanghai Cancer Center Shanghai China.
  • Han X; Department of Oncology Shanghai Medical College, Fudan University Shanghai China.
  • Luo H; Precision Cancer Medical Center Fudan University Shanghai Cancer Center Shanghai China.
  • Nasir J; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery Fudan University Shanghai Cancer Center Shanghai China.
  • Chen C; Department of Oncology Shanghai Medical College, Fudan University Shanghai China.
  • Shao Z; Precision Cancer Medical Center Fudan University Shanghai Cancer Center Shanghai China.
  • Ling H; Precision Cancer Medical Center Fudan University Shanghai Cancer Center Shanghai China.
  • Hu X; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery Fudan University Shanghai Cancer Center Shanghai China.
Cancer Innov ; 3(5): e146, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39301202
ABSTRACT

Background:

Triple-negative breast cancer (TNBC) displays high heterogeneity. The majority of TNBC cases are characterized by high Ki-67 expression. TNBC with low Ki-67 expression accounts for only a small fraction of cases and has been relatively less studied.

Methods:

This study analyzed a large single-center multiomics TNBC data set, combined with a single-cell data set. The clinical, genomic, and metabolic characteristics of patients with low Ki-67 TNBC were analyzed.

Results:

The clinical and pathological characteristics were analyzed in 2217 TNBC patients. Low Ki-67 TNBC was associated with a higher patient age at diagnosis, a lower proportion of invasive ductal carcinoma, increased alterations in the PI3K-AKT-mTOR pathway, upregulated lipid metabolism pathways, and enhanced infiltration of M2 macrophages. High Ki-67 TNBC exhibited a higher prevalence of TP53 gene mutations, elevated nucleotide metabolism, and increased infiltration of M1 macrophages.

Conclusions:

We identified specific genomic and metabolic characteristics unique to low Ki-67 TNBC, which have implications for the development of precision therapies and patient stratification strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancer Innov Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancer Innov Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido