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Protocol for a systematic review and meta-analysis investigating the impact of continuous versus intermittent enteral feeding in critically ill patients.
Acharya, Lydia S; Clayton, Anne M; Mbuagbaw, Lawrence; Oczkowski, Simon; Rochwerg, Bram; Tsang, Jennifer; Campbell, Kaitryn; Dearness, Karin; Dionne, Joanna C.
Afiliación
  • Acharya LS; Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada. lacha042@uottawa.ca.
  • Clayton AM; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
  • Mbuagbaw L; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
  • Oczkowski S; St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
  • Rochwerg B; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
  • Tsang J; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
  • Campbell K; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
  • Dearness K; St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
  • Dionne JC; St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Syst Rev ; 13(1): 239, 2024 Sep 19.
Article en En | MEDLINE | ID: mdl-39300571
ABSTRACT

INTRODUCTION:

Enteral nutrition (EN) is the recommended nutritional support in most critically ill populations. When given by feeding tube, EN may be administered either continuously or intermittently. It is unclear which approach is superior in reducing gastrointestinal complications-such as diarrhea-and meeting nutritional targets. The main objectives of this systematic review and meta-analysis are to (1) determine whether continuous or intermittent enteral nutrition is associated with higher incidence of adverse gastrointestinal outcomes, including diarrhea, and (2) determine which feeding modality is associated with reaching nutritional goals. METHODS AND

ANALYSIS:

This systematic review protocol is reported in accordance with guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement. We will search MEDLINE, Embase, the Cochrane Library, and the World Health Organization (WHO) International Clinical Trials Registry (ICTRP) search portal for studies comparing continuous EN and intermittent EN in critically ill patients with no date or language restrictions. Studies will be screened, selected, and extracted independently and in duplicate. We will assess the risk-of-bias assessment using the Cochrane Collaboration's Risk of Bias (RoB) 2 tool. The primary outcome will include the incidence of diarrhea; secondary outcomes include other adverse GI outcomes (nausea, vomiting, abdominal pain, and constipation), as well as reaching nutritional goals, and length of ICU and hospital stay and mortality. We will pool data using a random-effects model and assess the certainty of the evidence for each outcome using Grading of Recommendations, Assessment, Development and Evaluations (GRADE) methodology. ETHICS AND DISSEMINATION Ethics approval is not required for this study as no original data will be collected. We will disseminate results through peer-reviewed publication and conference presentations. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42022330118.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Nutrición Enteral / Diarrea Límite: Humans Idioma: En Revista: Syst Rev Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Nutrición Enteral / Diarrea Límite: Humans Idioma: En Revista: Syst Rev Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido