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Long non-coding RNA PVT1 regulates TGF-ß and promotes the proliferation, migration and invasion of hypopharyngeal carcinoma FaDu cells.
Zhao, Yan; Zhao, Lei; Li, Maocai; Meng, Zhen; Wang, Song; Li, Jun; Li, Lianqing; Gong, Lili.
Afiliación
  • Zhao Y; Department of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Liaocheng, Shandong, China.
  • Zhao L; Department of Otorhinolaryngology, Heze Municipal Hospital, Heze, Shandong, China.
  • Li M; Department of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital, No.67, Dongchang West Road, Liaocheng, Shandong, 252000, China.
  • Meng Z; Biomedical Laboratory, Medical School of Liaocheng University, Liaocheng, Shandong, China.
  • Wang S; Precision Biomedical Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Li J; Precision Biomedical Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Li L; Department of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital, No.67, Dongchang West Road, Liaocheng, Shandong, 252000, China. lilianqing1979@163.com.
  • Gong L; Department of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital, No.67, Dongchang West Road, Liaocheng, Shandong, 252000, China. gll79wm@aliyun.com.
World J Surg Oncol ; 22(1): 254, 2024 Sep 20.
Article en En | MEDLINE | ID: mdl-39300515
ABSTRACT
Hypopharyngeal carcinoma is one of the malignant tumors of the head and neck with a particularly poor prognosis. Recurrence and metastasis are important reasons for poor prognosis of hypopharyngeal cancer patients, and malignant proliferation, migration, and invasion of tumor cells are important factors for recurrence and metastasis of hypopharyngeal cancer. Therefore, elucidating hypopharyngeal cancer cells' proliferation, migration, and invasion mechanism is essential for improving diagnosis, treatment, and prognosis. Plasmacytoma Variant Translocation 1 (PVT1) is considered a potential diagnostic marker and therapeutic target for tumors. However, it remains unclear whether PVT1 is related to the occurrence and development of hypopharyngeal cancer and its specific mechanism. In this study, the promoting effect of PVT1 on the proliferation, migration, and invasion of hypopharyngeal carcinoma FaDu cells was verified by cell biology experiments and animal studies, and it was found that PVT1 inhibited the expression of TGF-ß, suggesting that PVT1 may regulate the occurrence and development of hypopharyngeal carcinoma FaDu cells through TGF-ß.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Hipofaríngeas / Regulación Neoplásica de la Expresión Génica / Movimiento Celular / Proliferación Celular / ARN Largo no Codificante / Invasividad Neoplásica Límite: Animals / Humans / Male Idioma: En Revista: World J Surg Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Hipofaríngeas / Regulación Neoplásica de la Expresión Génica / Movimiento Celular / Proliferación Celular / ARN Largo no Codificante / Invasividad Neoplásica Límite: Animals / Humans / Male Idioma: En Revista: World J Surg Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido