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The inertial-based gait normalcy index of dual task cost during turning quantifies gait automaticity improvement in early-stage Parkinson's rehabilitation.
Meng, Lin; Shi, Yu; Zhao, Hongbo; Wang, Deyu; Zhu, Xiaodong; Ming, Dong.
Afiliación
  • Meng L; Academy of Medical Engineering and Translational Medicine, Medical School, Faculty of Medicine, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, China. linmeng@tju.edu.cn.
  • Shi Y; Haihe Laboratory of Brain-computer Interaction and Human-machine Integration, No. 26 Ziyuan Road, Xiqing District, Tianjin, 300392, China. linmeng@tju.edu.cn.
  • Zhao H; Academy of Medical Engineering and Translational Medicine, Medical School, Faculty of Medicine, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, China.
  • Wang D; Academy of Medical Engineering and Translational Medicine, Medical School, Faculty of Medicine, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, China.
  • Zhu X; Academy of Medical Engineering and Translational Medicine, Medical School, Faculty of Medicine, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, China.
  • Ming D; Department of Neurology, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, China. zxd3516@tmu.edu.cn.
J Neuroeng Rehabil ; 21(1): 166, 2024 Sep 19.
Article en En | MEDLINE | ID: mdl-39300485
ABSTRACT

BACKGROUND:

The loss of gait automaticity is a key cause of motor deficits in Parkinson's disease (PD) patients, even at the early stage of the disease. Action observation training (AOT) shows promise in enhancing gait automaticity. However, effective assessment methods are lacking. We aimed to propose a novel gait normalcy index based on dual task cost (NIDTC) and evaluate its validity and responsiveness for early-stage PD rehabilitation.

METHODS:

Thirty early-stage PD patients were recruited and randomly assigned to the AOT or active control (CON) group. The proposed NIDTC during straight walking and turning tasks and clinical scale scores were measured before and after 12 weeks of rehabilitation. The correlations between the NIDTCs and clinical scores were analyzed with Pearson correlation coefficient analysis to evaluate the construct validity. The rehabilitative changes were assessed using repeated-measures ANOVA, while the responsiveness of NIDTC was further compared by t tests.

RESULTS:

The turning-based NIDTC was significantly correlated with multiple clinical scales. Significant group-time interactions were observed for the turning-based NIDTC (F = 4.669, p = 0.042), BBS (F = 6.050, p = 0.022) and PDQ-39 (F = 7.772, p = 0.011) tests. The turning-based NIDTC reflected different rehabilitation effects between the AOT and CON groups, with the largest effect size (p = 0.020, Cohen's d = 0.933).

CONCLUSION:

The turning-based NIDTC exhibited the highest responsiveness for identifying gait automaticity improvement by providing a comprehensive representation of motor ability during dual tasks. It has great potential as a valid measure for early-stage PD diagnosis and rehabilitation assessment. Trial registration Chinese Clinical Trial Registry ChiCTR2300067657.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Marcha Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroeng Rehabil Asunto de la revista: ENGENHARIA BIOMEDICA / NEUROLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Marcha Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroeng Rehabil Asunto de la revista: ENGENHARIA BIOMEDICA / NEUROLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido