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The splicing factor hnRNPL demonstrates conserved myocardial regulation across species and is altered in heart failure.
Draper, Isabelle; Huang, Wanting; Pande, Suchita; Zou, Aaron; Calamaras, Timothy D; Choe, Richard H; Correia-Branco, Ana; Mei, Ariel L; Chen, Howard H; Littel, Hannah R; Gunasekaran, Mekala; Wells, Natalya M; Bruels, Christine C; Daugherty, Audrey L; Wolf, Matthew J; Kang, Peter B; Yang, Vicky K; Slonim, Donna K; Wallingford, Mary C; Blanton, Robert M.
Afiliación
  • Draper I; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Huang W; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Pande S; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Zou A; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Calamaras TD; Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Choe RH; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Correia-Branco A; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Mei AL; Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Chen HH; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Littel HR; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
  • Gunasekaran M; Greg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Wells NM; Greg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Bruels CC; Greg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Daugherty AL; Greg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Wolf MJ; Greg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Kang PB; Division of Cardiology, University of Virginia, Charlottesville, VA, USA.
  • Yang VK; Greg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Slonim DK; Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
  • Wallingford MC; Department of Computer Science, Tufts University, Medford, MA, USA.
  • Blanton RM; Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.
FEBS Lett ; 2024 Sep 19.
Article en En | MEDLINE | ID: mdl-39300280
ABSTRACT
Heart failure (HF) is highly prevalent. Mechanisms underlying HF remain incompletely understood. Splicing factors (SF), which control pre-mRNA alternative splicing, regulate cardiac structure and function. This study investigated regulation of the splicing factor heterogeneous nuclear ribonucleoprotein-L (hnRNPL) in the failing heart. hnRNPL protein increased in left ventricular tissue from mice with transaortic constriction-induced HF and from HF patients. In left ventricular tissue, hnRNPL was detected predominantly in nuclei. Knockdown of the hnRNPL homolog Smooth in Drosophila induced cardiomyopathy. Computational analysis of predicted mouse and human hnRNPL binding sites suggested hnRNPL-mediated alternative splicing of tropomyosin, which was confirmed in C2C12 myoblasts. These findings identify hnRNPL as a sensor of cardiac dysfunction and suggest that disturbances of hnRNPL affect alternative splicing in HF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: FEBS Lett Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: FEBS Lett Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido