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Insights into Long COVID: Unraveling Risk Factors, Clinical Features, Radiological Findings, Functional Sequelae and Correlations: A Retrospective Cohort Study.
Pasculli, Patrizia; Zingaropoli, Maria Antonella; Dominelli, Federica; Solimini, Angelo Giuseppe; Masci, Giorgio Maria; Birtolo, Lucia Ilaria; Pasquariello, Lara; Paribeni, Filippo; Iafrate, Franco; Panebianco, Valeria; Galardo, Gioacchino; Mancone, Massimo; Catalano, Carlo; Pugliese, Francesco; Palange, Paolo; Mastroianni, Claudio Maria; Ciardi, Maria Rosa.
Afiliación
  • Pasculli P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. Electronic address: patrizia.pasculli@uniroma1.it.
  • Zingaropoli MA; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Dominelli F; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Solimini AG; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Masci GM; Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
  • Birtolo LI; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza, University of Rome, 00161, Rome, Italy.
  • Pasquariello L; Department of Public Health and Infectious Diseases, Division of Pulmonary Medicine, Policlinico Umberto I Hospital, 00161, Rome, Italy.
  • Paribeni F; Department of Specialist Surgery and Organ Transplantation "Paride Stefanini", Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
  • Iafrate F; Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
  • Panebianco V; Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
  • Galardo G; Medical Emergency Unit, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy.
  • Mancone M; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza, University of Rome, 00161, Rome, Italy.
  • Catalano C; Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
  • Pugliese F; Department of Specialist Surgery and Organ Transplantation "Paride Stefanini", Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
  • Palange P; Department of Public Health and Infectious Diseases, Division of Pulmonary Medicine, Policlinico Umberto I Hospital, 00161, Rome, Italy.
  • Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Ciardi MR; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Am J Med ; 2024 Sep 17.
Article en En | MEDLINE | ID: mdl-39299642
ABSTRACT

BACKGROUND:

The long-term symptomatology of COVID-19 has yet to be comprehensively described. The aim of the study was to describe persistent COVID-19 symptoms in a cohort of hospitalized and home-isolated patients.

METHODS:

A retrospective cohort study was conducted on long COVID patients. Long COVID symptoms were identified, and patients were divided into hospitalized (in-patients) and home-isolated (out-patients) as well as according to the number of symptoms. Patients were examined by a multydisciplinary medical team. Blood tests, high resolution chest computed tomography (CT), physical and infectious examination were performed. Finally, in-patients were evaluated at two time-points on hospital admission (T0) and after three months from discharge (Tpost).

RESULTS:

Three hundred and sixty-four COVID-19 patients were enrolled. 82% of patients reported at least one or more symptoms. The most reported symptom was fatigue. Chest CT showed alteration in 76% of patients and pulmonary function alterations were observed in 44.7% of patients. A higher risk of presenting at least one symptom was seen in patients treated with corticosteroid and a higher risk of presenting chest CT residual lesion was observed in hospitalized patients and in patients that received hydroxychloroquine treatment. Moreover, a higher risk of altered pulmonary function was observed in older patients.

CONCLUSION:

Long-term sequelae are present in a remarkable number of long COVID patients and pose a new challenge to the healthcare system to identify long-lasting effects and improve patients' wellbeing. Multi-disciplinary teams are crucial to develop preventive measures, and clinical management strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos