Your browser doesn't support javascript.
loading
Osteoporosis screening using QCT-based cutoff value of Hounsfield units in patients with degenerative lumbar diseases.
Zou, Da; He, Xuan; Shang, Zesen; Jin, Dan; Li, Weishi.
Afiliación
  • Zou D; Orthopaedics Department, Peking University Third Hospital, Haidian, Beijing, China.
  • He X; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Haidian, China.
  • Shang Z; Orthopaedics Department, Peking University Third Hospital, Haidian, Beijing, China.
  • Jin D; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Haidian, China.
  • Li W; Orthopaedics Department, Peking University Third Hospital, Haidian, Beijing, China.
Eur Spine J ; 2024 Sep 19.
Article en En | MEDLINE | ID: mdl-39297897
ABSTRACT

PURPOSE:

In patients with degenerative lumbar diseases, we aimed to establish the cutoff value of Hounsfield units (HU) for osteoporosis screening on the basis of the relationship between computed tomography (CT) HU value and volume bone mineral density (BMD) measured by quantitative computed tomography (QCT).

METHODS:

A total of 136 patients aged ≥ 50 years with degenerative lumbar diseases were retrospectively included. Their QCT-BMD of L1-2 were recorded, and the CT values of L1-2 were measured with the same CT images of QCT. The degree of bone loss was evaluated with the criteria based on QCT-BMD cutoff value of 80 mg/cm3 for osteoporosis and cutoff value of 120 mg/cm3 for osteopenia. The cutoff of CT value was acquired according to the linear regression equation between CT value and QCT-BMD.

RESULTS:

The rate of osteoporosis, osteopenia, normal BMD was 33.8% (46/136), 51.5% (70/136), and 14.7% (20/136), respectively. The Pearson correlation coefficients between CT value and QCT-BMD were over 0.9 (P < 0.05). The cutoff of average CT value of L1-2 was calculated and adjusted to 110HU for osteoporosis and 160HU for osteopenia according the equation average QCT-BMD of L1-2 = 0.76 âœ• average CT value of L1-2-0.46 (R2 = 0.931, P < 0.001). Cutoff value of 110HU was 91.2% (42/46) sensitive and 88.9% (80/90) specific for identifying osteoporosis. The cutoff value of 160HU was 95.0% (19/20) sensitive and 96.6% (112/116) specific for distinguishing normal BMD from abnormal BMD (osteoporosis and osteopenia).

CONCLUSION:

The CT value is effective in osteoporosis screening, and the QCT-based cutoff value is 110 HU for osteoporosis and 160 HU for osteopenia in the patients with degenerative lumbar disease.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Spine J Asunto de la revista: ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Spine J Asunto de la revista: ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania