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Evaluation of serum NFL, T-tau, p-tau181, p-tau217, Aß40 and Aß42 for the diagnosis of neurodegenerative diseases.
Kahouadji, Samy; Pereira, Bruno; Sapin, Vincent; Valentin, Audrey; Bonnet, Agathe; Dionet, Elsa; Durif, Julie; Lahaye, Clément; Boisgard, Stéphane; Moisset, Xavier; Bouvier, Damien.
Afiliación
  • Kahouadji S; Biochemistry and Molecular Genetic Department, 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
  • Pereira B; Université Clermont Auvergne, CNRS, INSERM, iGReD, Clermont-Ferrand, France.
  • Sapin V; Biostatistics Unit (DRCI), 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
  • Valentin A; Biochemistry and Molecular Genetic Department, 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
  • Bonnet A; Université Clermont Auvergne, CNRS, INSERM, iGReD, Clermont-Ferrand, France.
  • Dionet E; Biochemistry and Molecular Genetic Department, 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
  • Durif J; Biochemistry and Molecular Genetic Department, 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
  • Lahaye C; Neurology Department, 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
  • Boisgard S; Biochemistry and Molecular Genetic Department, 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
  • Moisset X; Geriatrics Department, 55174 Université Clermont Auvergne, INRAE UMR 1019 Human Nutrition Research Unit, CRNH Auvergne, CHU Clermont-Ferrand , Clermont-Ferrand, France.
  • Bouvier D; 55174 Université Clermont Auvergne, Clermont Auvergne INP, CNRS, CHU Clermont-Ferrand, ICCF , Clermont-Ferrand, France.
Clin Chem Lab Med ; 2024 Sep 20.
Article en En | MEDLINE | ID: mdl-39297506
ABSTRACT

OBJECTIVES:

To assess the variations and diagnostic performance of serum biomarkers of neurodegenerative diseases.

METHODS:

In this monocentric prospective study, neurofilament light (NFL), T-tau, p-tau181, p-tau217, Aß40, and Aß42 were measured in serum collected from orthopedic patients (control group, n=114) and patients in the neurology department (n=69) previously diagnosed with Alzheimer's disease (AD, n=52), parkinsonian syndromes (n=10), and other etiologies of neurodegeneration (non-AD, n=7).

RESULTS:

In the control group, serum NFL, T-tau, p-tau181, p-tau217, and Aß40 significantly increased with age, independently of sex. NFL (p=0.0078), p-tau217 (p<0.001) were significantly increased with neurodegeneration when compared to controls, with only p-tau217 significant in the multivariate analysis (p<0.001). Multivariate regression analysis accounting for age highlighted a significant increase of p-tau217 (p<0.001) in the AD subgroup. NFL was significantly increased in the non-AD patients (p<0.001), and in the parkinsonian syndromes subgroup (p=0.016) when compared to negative controls. Serum p-tau181 and p-tau217 were significantly correlated with CSF p-tau181 (Spearman's coefficients of 0.43 and 0.48 respectively, n=40). Areas under the ROC curves for the identification of patients with neurodegenerative diseases were 0.62 (0.54-0.70) for NFL, 0.62 (0.54-0.71) for T-tau, 0.83 (0.76-0.89) for p-tau217, and 0.66 (0.58-0.74) for Aß40.

CONCLUSIONS:

Serum biomarkers can help identify patients with neurodegenerative disease and may be a valuable tool for care and orientation. Phosphorylated tau p-tau217 is a promising blood biomarker for AD and NFL for other etiologies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Chem Lab Med Asunto de la revista: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Chem Lab Med Asunto de la revista: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania