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Association Between Clonal Hematopoiesis and Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy.
Inoue, Shunsuke; Ko, Toshiyuki; Shindo, Akito; Nomura, Seitaro; Yamada, Takanobu; Jimba, Takahiro; Dai, Zhehao; Nakao, Harumi; Suzuki, Atsushi; Kashimura, Takeshi; Iwahana, Togo; Goto, Keiko; Matsushima, Shouji; Ishida, Junichi; Amiya, Eisuke; Zhang, Bo; Kubota, Masayuki; Sawami, Kosuke; Heryed, Tuolisi; Yamada, Shintaro; Katoh, Manami; Katagiri, Mikako; Ito, Masamichi; Nayakama, Yukiteru; Fujiu, Katsuhito; Hatano, Masaru; Takeda, Norifumi; Takimoto, Eiki; Akazawa, Hiroshi; Morita, Hiroyuki; Yamaguchi, Junichi; Inomata, Takayuki; Kobayashi, Yoshio; Minamino, Tohru; Tsutsui, Hiroyuki; Kurokawa, Mineo; Aiba, Atsu; Aburatani, Hiroyuki; Komuro, Issei.
Afiliación
  • Inoue S; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Ko T; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Shindo A; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Nomura S; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Yamada T; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Jimba T; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Dai Z; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Nakao H; Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Suzuki A; Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
  • Kashimura T; Department of Cardiovascular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
  • Iwahana T; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Goto K; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Matsushima S; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Ishida J; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Amiya E; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Zhang B; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kubota M; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Sawami K; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Heryed T; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Yamada S; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Katoh M; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Katagiri M; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Ito M; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Nayakama Y; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Fujiu K; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Hatano M; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Takeda N; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Takimoto E; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Akazawa H; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Morita H; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Yamaguchi J; Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
  • Inomata T; Department of Cardiovascular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
  • Kobayashi Y; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Minamino T; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Tsutsui H; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Kurokawa M; School of Medicine and Graduate School, International University of Health and Welfare, Okawa City, Japan.
  • Aiba A; Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Aburatani H; Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Komuro I; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
JACC Basic Transl Sci ; 9(8): 956-967, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39297129
ABSTRACT
Although clonal hematopoiesis of indeterminate potential (CHIP) is an adverse prognostic factor for atherosclerotic disease, its impact on nonischemic dilated cardiomyopathy (DCM) is elusive. The authors performed whole-exome sequencing and deep target sequencing among 198 patients with DCM and detected germline mutations in cardiomyopathy-related genes and somatic mutations in CHIP driver genes. Twenty-five CHIP driver mutations were detected in 22 patients with DCM. Ninety-two patients had cardiomyopathy-related pathogenic mutations. Multivariable analysis revealed that CHIP was an independent risk factor of left ventricular reverse remodeling, irrespective of known prognostic factors. CHIP exacerbated cardiac systolic dysfunction and fibrosis in a DCM murine model. The identification of germline and somatic mutations in patients with DCM predicts clinical prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos