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Proliferative vitreoretinopathy and its relationship with inflammatory serum biomarkers.
Martinez Pacheco, Victor Alejandro; Rojas Juarez, Sergio; Velasco Sepulveda, Braulio Hernan; Ramirez Estudillo, Abel.
Afiliación
  • Martinez Pacheco VA; Hospital de Nuestra Señora de la Luz, Retina and Vitreous Department, Mexico City 06030, Mexico.
  • Rojas Juarez S; Hospital de Nuestra Señora de la Luz, Retina and Vitreous Department, Mexico City 06030, Mexico.
  • Velasco Sepulveda BH; Instituto de Oftlamología FAP Conde de Valenciana, Mexico City 06080, Mexico.
  • Ramirez Estudillo A; Hospital de Nuestra Señora de la Luz, Retina and Vitreous Department, Mexico City 06030, Mexico.
Int J Ophthalmol ; 17(9): 1659-1664, 2024.
Article en En | MEDLINE | ID: mdl-39296565
ABSTRACT

AIM:

To analyze if a relationship between levels of inflammatory serum biomarkers and severity of primary proliferative vitreoretinopathy (PVR) exists.

METHODS:

A retrospective case-control study. The healthy adult patients with rhegmatogenous retinal detachment and primary PVR were included in the PVR group. For the control group, healthy adults who underwent cataract surgery were included. The grade of PVR was classified according to the Retinal Society Terminology Committee. Blood samples were obtained before surgery, and processed in MYTHIC 18. Measures of interest were neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), the time between the decrease in visual acuity and surgery, PVR grade, type of surgery, final best corrected visual acuity, and rate of re-detachment.

RESULTS:

Totally 240 patients were included, 120 in each group, 79 (65.8%) and 56 (46.7%) were male in the PVR and control group, respectively. PVR A had greater levels of monocytes (0.28±0.18 vs 0.12±0.32, P=0.002), neutrophils (4.59±1.51 vs 3.92±1.27, P=0.006), and LMR (9.32±4.42 vs 7.43±3.90, P=0.01). PVR B had a greater monocyte count (0.30±0.13 vs 0.12±0.32, P=0.001), and PVR C demonstrated higher levels in monocytes (0.27±0.12 vs 0.12±0.32, P=0.004), neutrophils (4.39±1.13 vs 3.92±1.27, P=0.004), and LMR (9.63±3.24 vs 7.43±3.90, P=0.002) compared to control, respectively. An LMR cut-off value of 9.38 predicted PVR with a sensibility of 54.2% and specificity of 77.5% and NLR cut-off of 1.70 predicted PVR with a sensibility of 62% and specificity of 54.2%.

CONCLUSION:

Patients with primary PVR demonstrate greater neutrophil, monocyte, and LMR levels than the control group. Cut-off values obtained from ratios could be useful in a clinical setting when no posterior view of the fundus is possible due to media opacity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: México Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: México Pais de publicación: China