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Effect of vascularized jejunal conduit flap on peripheral nerve regeneration in rats.
Ismayilzade, Majid; Ince, Bilsev; Oltulu, Pembe; Baycar, Zikrullah; Kendir, Münür Selçuk; Dadaci, Mehmet.
Afiliación
  • Ismayilzade M; Department of Plastic, Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Istinye University, Istanbul, Turkiye.
  • Ince B; Department of Plastic, Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkiye.
  • Oltulu P; Department of Pathology, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkiye.
  • Baycar Z; Department of Plastic, Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkiye.
  • Kendir MS; Department of Plastic, Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkiye.
  • Dadaci M; Department of Plastic, Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkiye.
Turk J Med Sci ; 54(4): 792-803, 2024.
Article en En | MEDLINE | ID: mdl-39295602
ABSTRACT
Background/

aim:

In the literature, almost all of the nerve conduits proposed for obtaining better nerve recovery were applied as graft materials. In this study, we aimed to propose a new nerve conduit model with a flap pattern and evaluate the effect of a pedicled vascularized jejunal flap on nerve regeneration after wrapping it around a sciatic nerve. Materials and

methods:

A total of 90 Wistar albino rats were randomly divided into nine groups with 10 rats in each. The first three groups constituted the control groups, whereas Groups 4-6 were the jejunum conduit (JC)-applied groups. A mucosa-resected JC (MRJC) was applied in Groups 7 and 8. Epineurial neurorrhaphy was performed in Groups 1, 4, and 7; repair with a nerve graft was applied in Groups 2, 5, and 8; and a 1-cm-long nerve defect was created in Groups 3, 6, and 9. After 2 months of follow-up, nerve regeneration was assessed by statistical analyses of the Sciatic Functional Index (SFI) and histopathological evaluation.

Results:

The MRJC groups had significantly better results in terms of SFI (p = 0.005). Statistical differences in axonal degeneration, axonal density, myelination, and disorganization were found between all control groups and MRJC groups (p = 0.022, p = 0.001, p = 0.001, and p = 0.039, respectively).

Conclusion:

In this study, the feasibility of wrapping around the nerve repair zones of pedicled autologous flaps designed in a tubular fashion was observed in a small rat model. The findings must be further validated with larger animals before clinical testing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nervio Ciático / Colgajos Quirúrgicos / Ratas Wistar / Yeyuno / Regeneración Nerviosa Límite: Animals Idioma: En Revista: Turk J Med Sci Año: 2024 Tipo del documento: Article Pais de publicación: Turquía
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nervio Ciático / Colgajos Quirúrgicos / Ratas Wistar / Yeyuno / Regeneración Nerviosa Límite: Animals Idioma: En Revista: Turk J Med Sci Año: 2024 Tipo del documento: Article Pais de publicación: Turquía