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Reductive stress in mitochondria isolated from the carotid body of type 1 diabetic male Wistar rats.
Tejeda-Chavez, Hector R; Montero, Sergio; Saavedra-Molina, Alfredo; Lemus, Monica; Tejeda-Luna, Julio B; Roces de Alvarez-Buylla, Elena.
Afiliación
  • Tejeda-Chavez HR; Faculty of Medicine, Colima of University, Colima, Mexico.
  • Montero S; Faculty of Medicine, Colima of University, Colima, Mexico.
  • Saavedra-Molina A; Department of Neuroendocrinology, University Center of Biomedical Research, Colima University, Colima, Mexico.
  • Lemus M; Institute of Biological Chemistry Research, UMSNH, Morelia, Michoacán, Mexico.
  • Tejeda-Luna JB; Department of Neuroendocrinology, University Center of Biomedical Research, Colima University, Colima, Mexico.
  • Roces de Alvarez-Buylla E; Faculty of Medicine, Colima of University, Colima, Mexico.
Physiol Rep ; 12(18): e70016, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39294856
ABSTRACT
The carotid body (CB) senses changes in arterial O2 partial pressure (pO2) and glucose levels; therefore, it is key for the detection of hypoxia and hypoglycemia. The CB has been suggested to detect pO2 through an increase in reactive oxygen species (ROS) in the mitochondria. However, the mechanism protecting the chemoreceptor cells and their mitochondria from ROS and hyperglycemia is poorly understood. Here we measured glutathione levels in CB mitochondria of control and in streptozotocin (STZ)-induced type 1 diabetic male Wistar rats. We found a dramatic reduction in total glutathione from 11.45 ± 1.30 µmol/mg protein in control rats to 1.45 ± 0.31 µmol/mg protein in diabetic rats. However, the ratio of reduced to oxidized glutathione, a measure of the redox index, was increased in diabetic rats compared to controls. We conclude that the mitochondria of CB chemoreceptor cells in type 1 diabetic male Wistar rats were likely under glutathione-reducing stress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerpo Carotídeo / Ratas Wistar / Diabetes Mellitus Experimental / Glutatión / Mitocondrias Límite: Animals Idioma: En Revista: Physiol Rep Año: 2024 Tipo del documento: Article País de afiliación: México Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerpo Carotídeo / Ratas Wistar / Diabetes Mellitus Experimental / Glutatión / Mitocondrias Límite: Animals Idioma: En Revista: Physiol Rep Año: 2024 Tipo del documento: Article País de afiliación: México Pais de publicación: Estados Unidos