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The effects of simvastatin on the bone microstructure and mechanics of ovariectomized mice: a micro-CT and micro-finite element analysis study.
Liang, Yanbo; Yuan, Xiaoqing; Dai, Xiaoxue; Zhang, Guohui; Li, Changqin; Yang, Hui; Zhang, Tingting; Qin, Jian.
Afiliación
  • Liang Y; Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, No.366 Taishan Street, Tai'an City, Shandong Province, 271000, China.
  • Yuan X; Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, No.366 Taishan Street, Tai'an City, Shandong Province, 271000, China.
  • Dai X; Chinese institutes for medical research, Capital Medical University, Beijing, 100050, China.
  • Zhang G; The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 271000, China.
  • Li C; Shandong First Medical University, Jinan, Shandong, 271000, China.
  • Yang H; Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, No.366 Taishan Street, Tai'an City, Shandong Province, 271000, China.
  • Zhang T; Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, No.366 Taishan Street, Tai'an City, Shandong Province, 271000, China.
  • Qin J; Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, No.366 Taishan Street, Tai'an City, Shandong Province, 271000, China.
BMC Musculoskelet Disord ; 25(1): 748, 2024 Sep 18.
Article en En | MEDLINE | ID: mdl-39294613
ABSTRACT

BACKGROUND:

Osteoporosis is a major health concern for postmenopausal women, and the effect of simvastatin (Sim) on bone metabolism is controversial. This study aimed to investigate the effect of simvastatin on the bone microstructure and bone mechanical properties in ovariectomized (OVX) mice.

METHODS:

24 female C57BL/6J mice (8-week-old) were randomly allocated into three groups including the OVX + Sim group, the OVX group and the control group. At 8 weeks after operation, the L4 vertebral bones were dissected completely for micro-Computed Tomography (micro-CT) scanning and micro-finite element analysis (µFEA). The differences between three groups were compared using ANOVA with a LSD correction, and the relationship between bone microstructure and mechanical properties was analyzed using linear regression.

RESULTS:

Bone volume fraction, trabecular number, connectivity density and trabecular tissue mineral density in the OVX + Sim group were significantly higher than those in the OVX group (P < 0.05). For the mechanical properties detected via µFEA, the OVX + Sim group had lower total deformation, equivalent elastic strain and equivalent stress compared to the OVX group (P < 0.05). In the three groups, the mechanical parameters were significantly correlated with bone volume fraction and trabecular bone mineral density.

CONCLUSIONS:

The findings suggested that simvastatin had a potential role in the treatment of osteoporosis. The results of this study could guide future research on simvastatin and support the development of simvastatin-based treatments to improve bone health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovariectomía / Densidad Ósea / Simvastatina / Análisis de Elementos Finitos / Microtomografía por Rayos X / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: BMC Musculoskelet Disord Asunto de la revista: FISIOLOGIA / ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovariectomía / Densidad Ósea / Simvastatina / Análisis de Elementos Finitos / Microtomografía por Rayos X / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: BMC Musculoskelet Disord Asunto de la revista: FISIOLOGIA / ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido