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Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives.
Rados, Magdalena; Landegger, Anna; Schmutzler, Lukas; Rabidou, Kimberlie; Taschner-Mandl, Sabine; Fetahu, Irfete S.
Afiliación
  • Rados M; St. Anna Children's Cancer Research Institute, Vienna, Austria.
  • Landegger A; Medical University of Innsbruck, Innsbruck, Austria.
  • Schmutzler L; Department of Otorhinolaryngology - Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
  • Rabidou K; Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA.
  • Taschner-Mandl S; St. Anna Children's Cancer Research Institute, Vienna, Austria.
  • Fetahu IS; Department of Neurology, Division of Neuropathology and Neurochemistry, Medical University of Vienna, Vienna, Austria. irfete.fetahu@meduniwien.ac.at.
Cancer Metastasis Rev ; 2024 Sep 18.
Article en En | MEDLINE | ID: mdl-39294470
ABSTRACT
Natural killer (NK) cells have multifaceted roles within the complex tumor milieu. They are pivotal components of innate immunity and shape the dynamic landscape of tumor-immune cell interactions, and thus can be leveraged for use in therapeutic interventions. NK-based immunotherapies have had remarkable success in hematological malignancies, but these therapies are met with many challenges in solid tumors, including neuroblastoma (NB), a childhood tumor arising from the sympathetic nervous system. With a focus on NB, this review outlines the mechanisms employed by NK cells to recognize and eliminate malignant cells, delving into the dynamic relationship between ligand-receptor interactions, cytokines, and other molecules that facilitate the cross talk between NK and NB cells. We discuss the immunomodulatory functions of NK cells and the mechanisms that contribute to loss of this immunosurveillance in NB, with a focus on how this dynamic has been utilized in recent immunotherapy advancements for NB.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancer Metastasis Rev Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancer Metastasis Rev Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos