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Altered development of the Hurst Exponent in medial prefrontal cortex in preschoolers with autism.
Linke, Annika C; Chen, Bosi; Olson, Lindsay; Cordova, Michaela; Wilkinson, Molly; Wang, Tiffany; Herrera, Meagan; Salmina, Madison; Rios, Adriana; Mahmalji, Judy; Do, Tess; Vu, Jessica; Budman, Michelle; Walker, Alexis; Fishman, Inna.
Afiliación
  • Linke AC; Department of Psychology, San Diego State University, San Diego, CA; SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA; SDSU Center for Autism and Developmental Disorders, San Diego, CA. Electronic address: alinke@sdsu.edu.
  • Chen B; SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA; Department of Child and Adolescent Psychiatry, New York University School of Medicine, New York, NY.
  • Olson L; SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA; University of California San Francisco, Department of Psychiatry and Behavioral Sciences, San Francisco, CA.
  • Cordova M; SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA.
  • Wilkinson M; SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA.
  • Wang T; Department of Psychology, University of California San Diego, La Jolla, CA.
  • Herrera M; Department of Psychology, San Diego State University, San Diego, CA.
  • Salmina M; Department of Psychology, San Diego State University, San Diego, CA.
  • Rios A; Department of Psychology, San Diego State University, San Diego, CA.
  • Mahmalji J; Department of Psychology, San Diego State University, San Diego, CA.
  • Do T; Department of Psychology, San Diego State University, San Diego, CA.
  • Vu J; Department of Psychology, San Diego State University, San Diego, CA.
  • Budman M; Department of Psychology, San Diego State University, San Diego, CA.
  • Walker A; Department of Psychology, San Diego State University, San Diego, CA.
  • Fishman I; Department of Psychology, San Diego State University, San Diego, CA; SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA; SDSU Center for Autism and Developmental Disorders, San Diego, CA.
Biol Psychiatry Cogn Neurosci Neuroimaging ; 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39293740
ABSTRACT

BACKGROUND:

Atypical balance of excitation (E) and inhibition (I) in the brain is thought to contribute to the emergence and symptomatology of autism spectrum disorders (ASD). E/I ratio can be estimated from resting state functional magnetic resonance imaging (fMRI) using the Hurst Exponent (H). A recent study reported decreased ventromedial prefrontal cortex (vmPFC) H in male adults with ASD. Part of the default mode network (DMN), vmPFC plays an important role in emotion regulation, decision making, and social cognition. It frequently shows altered function and connectivity in autistic individuals.

METHODS:

The current study presents the first fMRI evidence of altered early development of vmPFC H and its link to DMN functional connectivity (FC) and emotional control in toddlers and preschoolers with ASD. 83 children (n=45 ASD), ages 1½ - 5 years, underwent natural sleep fMRI as part of a longitudinal study.

RESULTS:

In a cross-sectional analysis, vmPFC H decreased with age in children with ASD, reflecting increasing E/I ratio, but not in typically developing children. This effect remained significant when controlling for gestational age at birth, socioeconomic status, or ethnicity. The same pattern was also observed in a subset of children with longitudinal fMRI data acquired two years apart on average. Lower vmPFC H was further associated with reduced FC within the DMN as well as with higher emotional control deficits (though only significant transdiagnostically).

CONCLUSIONS:

These results suggest an early onset of E/I imbalances in vmPFC in ASD with likely consequences for the maturation of the DMN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Psychiatry Cogn Neurosci Neuroimaging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Psychiatry Cogn Neurosci Neuroimaging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos