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The association between perinatal depressive symptoms and child neurodevelopment.
Miller, Emily S; Costantine, Maged M; Mele, Lisa; Varner, Michael W; Reddy, Uma M; Wapner, Ronald J; Thorp, John M; Saade, George R; Tita, Alan T N; Rouse, Dwight J; Sibai, Baha; Mercer, Brian M; Caritis, Steve N; Casey, Brian M.
Afiliación
  • Miller ES; Departments of Obstetrics and Gynecology of Northwestern University, Chicago, IL (Miller). Electronic address: EmMiller@wihri.org.
  • Costantine MM; The Ohio State University, Columbus, OH (Costantine).
  • Mele L; George Washington University Biostatistics Center, Washington, DC (Mele).
  • Varner MW; University of Utah Health Sciences Center, Salt Lake City, UT (Varner).
  • Reddy UM; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (Reddy).
  • Wapner RJ; Columbia University, New York, NY (Wapner).
  • Thorp JM; University of North Carolina, Chapel Hill, NC (Thorp).
  • Saade GR; University of Texas Medical Branch, Galveston, TX (Saade).
  • Tita ATN; University of Alabama at Birmingham, Birmingham, AL (Tita).
  • Rouse DJ; Brown University, Providence, RI (Rouse).
  • Sibai B; University of Texas-Houston, Houston, TX (Sibai).
  • Mercer BM; Case Western Reserve University, Cleveland, OH (Mercer).
  • Caritis SN; University of Pittsburgh, Pittsburgh, PA (Caritis).
  • Casey BM; University of Texas-Southwestern, Dallas, TX (Casey).
Am J Obstet Gynecol MFM ; 6(11): 101488, 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39293588
ABSTRACT

BACKGROUND:

Perinatal depression has been suggested to adversely impact child neurodevelopment. However, the complexity of the early childhood environment challenges conclusive findings.

OBJECTIVE:

To evaluate whether there is an association between perinatal depressive symptoms and child intelligence quotient (IQ) at 5 years of age. STUDY

DESIGN:

Secondary analysis of an ancillary study to a multicenter randomized trial of thyroxine therapy for pregnant individuals with subclinical hypothyroidism. Dyads of infants and birthing parent, with completed Center for Epidemiological Studies-Depression (CES-D) screens during pregnancy and postpartum and child neurodevelopment testing completed at five years of age (n=209) were included. CES-D screening was performed at 11-20 weeks, 34-38 weeks, and one-year postpartum. Depressive symptoms were categorized as antenatal (i.e., a positive screen at any point during pregnancy) or postpartum. The primary outcome was child IQ score < 85 at 5 years of age using the Wechsler Preschool and Primary Scale of Intelligence III (WPPSI-III) Full Scale test. Secondary outcomes included other assessments of childhood neurodevelopment. Bivariable analyses and multivariable logistic regressions were utilized.

RESULTS:

Of the 209 birthing people included, 72 (34%) screened positive for depression during pregnancy and 32 (15%) screened positive one year postpartum. Children born to individuals with a positive antenatal depression screen had a higher odds of IQ < 85 at 5 years of age compared with children born to individuals with a CES-D < 16 (35% vs. 18%, OR 2.4, 95% CI 1.2-4.7). Similar findings were seen for children born to individuals with a positive postpartum depression screen (47% vs. 21%, OR 3.3, 95% CI 1.5-7.3). These associations did not persist in multivariable analyses that controlled for social determinants of health and clinical characteristics (adjusted odd ratio [aOR] 1.4, 95% CI 0.7-3.1; aOR 2.1, 95% CI 0.9-5.1, for antenatal and postpartum depressive symptoms, respectively). Similar findings were observed for other adverse neurodevelopmental outcomes.

CONCLUSIONS:

Having a positive perinatal depression screen was not associated with child cognitive outcomes after controlling for covariates including social determinants of health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Obstet Gynecol MFM Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Obstet Gynecol MFM Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos