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Physical activity and sedentary behaviour in relation to body composition, estimated insulin sensitivity and arterial stiffness in adults with type 1 diabetes.
Helleputte, Simon; Stautemas, Jan; De Craemer, Marieke; Bogaert, Lotte; De Backer, Tine; Calders, Patrick; Lapauw, Bruno.
Afiliación
  • Helleputte S; Faculty of Medicine and Health Sciences, Ghent University, Belgium; Fonds Wetenschappelijk Onderzoek (FWO) Vlaanderen, Belgium. Electronic address: Simon.Helleputte@ugent.be.
  • Stautemas J; Faculty of Medicine and Health Sciences, Ghent University, Belgium.
  • De Craemer M; Faculty of Medicine and Health Sciences, Ghent University, Belgium.
  • Bogaert L; Faculty of Medicine and Health Sciences, Ghent University, Belgium.
  • De Backer T; Faculty of Medicine and Health Sciences, Ghent University, Belgium; Department of Cardiology, Ghent University Hospital, Belgium.
  • Calders P; Faculty of Medicine and Health Sciences, Ghent University, Belgium.
  • Lapauw B; Faculty of Medicine and Health Sciences, Ghent University, Belgium; Department of Endocrinology, Ghent University Hospital, Belgium.
Diabetes Res Clin Pract ; : 111860, 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39293499
ABSTRACT

AIMS:

To examine the association of daily PA levels and sedentary behaviour with body composition, estimated insulin sensitivity, and arterial stiffness in adults with type 1 diabetes (T1D).

METHODS:

Cross-sectional study in adults with T1D (n = 54). PA levels (daily steps, and time in moderate-to-vigorous intensity PA (MVPA)) and sedentary behaviour were measured using accelerometry for 7 days (McRoberts® DynaPort MoveMonitor). Cardiopulmonary exercise test for VO2max. Anthropometrics were collected, and body composition (total and % of fat mass (FMtot, FM%), total and % of lean mass (LMtot, LM%), and estimated visceral adipose tissue (VAT)) volume was assessed with dual energy X-ray-absorptiometry (DXA). Estimates of insulin sensitivity were determined (estimated glucose disposal rate (eGDR) and total daily insulin dose). Arterial stiffness was assessed with carotid-femoral pulse wave velocity (cf-PWV (m/s); SphygmoCor®).

RESULTS:

Lower 10-years HbA1c associated moderately with all PA measures. Favourable moderate associations were also found between PA measures and BMI, waist, VAT but not FM and LM. PA measures were favourably associated with a lower total daily insulin dose and higher eGDR. All PA parameters associated moderately with cf-PWV however not independent from traditional risk factors. VO2max inversely associated with cf-PWV independent of age, T1D duration and 24-hour mean blood pressure.

CONCLUSIONS:

Higher levels of PA, lower sedentary behaviour and greater exercise capacity are favourably associated with long-term glycaemic control, body composition, insulin dosage, estimated insulin sensitivity and arterial stiffness in adults with T1D. Therefore, regular PA and limiting sedentary time should be encouraged to improve metabolic and cardiovascular health in this population. Future longitudinal studies should explore mutual interactions and synergistic effects of PA on these outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda