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Protein-bound and free glycation compounds in human milk: A comparative study with minimally processed infant formula and pasteurized bovine milk.
Arena, Simona; De Pascale, Sabrina; Ciaravolo, Valentina; Monroy, Mariela Mejia; Gouw, Joost W; Stahl, Bernd; Bäuerl, Christine; Collado, Maria Carmen; De Filippo, Carlotta; Scaloni, Andrea; Troise, Antonio Dario.
Afiliación
  • Arena S; Proteomics, Metabolomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment, National Research Council (ISPAAM-CNR), Portici, Italy.
  • De Pascale S; Proteomics, Metabolomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment, National Research Council (ISPAAM-CNR), Portici, Italy.
  • Ciaravolo V; Proteomics, Metabolomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment, National Research Council (ISPAAM-CNR), Portici, Italy.
  • Monroy MM; Institute of Agricultural Biology and Biotechnology, National Research Council (IBBA-CNR), Pisa, Italy; NEUROFARBA Department, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
  • Gouw JW; Danone Research & Innovation, 3584, CT, Utrecht, the Netherlands.
  • Stahl B; Danone Research & Innovation, 3584, CT, Utrecht, the Netherlands.
  • Bäuerl C; Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain.
  • Collado MC; Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain.
  • De Filippo C; Institute of Agricultural Biology and Biotechnology, National Research Council (IBBA-CNR), Pisa, Italy.
  • Scaloni A; Proteomics, Metabolomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment, National Research Council (ISPAAM-CNR), Portici, Italy.
  • Troise AD; Proteomics, Metabolomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment, National Research Council (ISPAAM-CNR), Portici, Italy. Electronic address: antonio.troise@wur.nl.
Food Chem ; 463(Pt 2): 141265, 2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39293376
ABSTRACT
The role of the Maillard reaction and the accumulation of non-enzymatic glycation compounds in human milk have been scarcely considered. In this study, we investigated the proteins most susceptible to glycation, the identity of the corresponding modified residues and the quantitative relationship between protein-bound and free glycation compounds in raw human milk and, for comparison, in minimally processed infant formula and pasteurized bovine milk. In human milk, total protein-bound lysine modifications were up to 10% of the counterparts in infant formula, while Nε-carboxymethyllysine reached up to 27% of the concentration in the other two products. We demonstrated that the concentration of free pyrraline and methylglyoxal-hydroimidazolone were of the same order of magnitude in the three milk types. Our results delineate how the occurrence of some glycation compounds in human milk can be an unavoidable part of the breastfeeding and not an exclusive attribute of infant formulas and pasteurized bovine milk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Chem Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Chem Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido