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Multi-functional PEEK implants enhance osseointegration in OVX rat by remodeling the bone immune microenvironment.
Zhang, Yinchang; Wang, Lei; Long, Xingchun; Yan, Chaoxi; Wang, Qiang; Huang, Degang; Ma, Tao; Lu, Xiao; Zhao, Jie; Yang, Xing; Zheng, Bin; Si, Weibing; Ning, Eryu.
Afiliación
  • Zhang Y; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
  • Wang L; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
  • Long X; Department of Orthopedics, Renmin Hospital of Zhijiang, Yichang, Hubei 443200, China.
  • Yan C; Department of Orthopedics, Renmin Hospital of Zhijiang, Yichang, Hubei 443200, China.
  • Wang Q; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
  • Huang D; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
  • Ma T; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
  • Lu X; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
  • Zhao J; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
  • Yang X; Orthopedics and Sports Medicine Center, the Affiliated Suzhou Hospital of Nanjing Medical University,Gusu School, Suzhou 215500, Jiangsu, China.
  • Zheng B; Orthopedics and Sports Medicine Center, the Affiliated Suzhou Hospital of Nanjing Medical University,Gusu School, Suzhou 215500, Jiangsu, China. Electronic address: 13861314838@163.com.
  • Si W; Orthopedics and Sports Medicine Center, the Affiliated Suzhou Hospital of Nanjing Medical University,Gusu School, Suzhou 215500, Jiangsu, China. Electronic address: si_weibing@hotmail.com.
  • Ning E; Orthopedics and Sports Medicine Center, the Affiliated Suzhou Hospital of Nanjing Medical University,Gusu School, Suzhou 215500, Jiangsu, China. Electronic address: ningeryu9010@126.com.
Colloids Surf B Biointerfaces ; 245: 114219, 2024 Sep 08.
Article en En | MEDLINE | ID: mdl-39293290
ABSTRACT
Osseointegration is significantly impeded in osteoporotic conditions due to the elevated levels of reactive oxygen species (ROS) and inflammation at the site of injury. To enhance bone regeneration in osteoporotic conditions, a modified polyether ether ketone (PEEK) implants was prepared, denoted as PEEK-PDA-Sr. The implants consisted of mussel adhesion layer with the conjugation of strontium (Sr) ions, which can constantly release Sr ions for up to 3 weeks. PEEK-PDA-Sr demonstrated excellent biocompatibility and effectively regulated intracellular ROS levels and macrophage differentiation. In addition, the PEEK-PDA-Sr facilitated the osteogenesis of bone marrow stromal cells (BMSCs). In the ovariectomized (OVX) rat model of osteoporosis, the PEEK-PDA-Sr exhibited raised osseointegration in the femoral bone defects. The PEEK-PDA-Sr can be used as an immunoregulator with enhanced osseointegration and osteogenesis both in vivo and in vitro, which provides an available approach to treat osteoporotic bone defects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos