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The Role of miRNA in Hyperthyroidism Induced by Excessive Iodine in Drinking Water.
Yang, Zhihan; Dong, Yishan; Wang, Shuo; He, Jing; Shen, Zheng; Cheng, Jin; Li, Jinyu; Liu, Qiaoling; Xu, Ziqi; Sun, Dianjun; Zhang, Wei.
Afiliación
  • Yang Z; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
  • Dong Y; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province &, Ministry of Health, (23618504), Harbin, 150081, China.
  • Wang S; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin, 150081, China.
  • He J; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
  • Shen Z; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province &, Ministry of Health, (23618504), Harbin, 150081, China.
  • Cheng J; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin, 150081, China.
  • Li J; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
  • Liu Q; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province &, Ministry of Health, (23618504), Harbin, 150081, China.
  • Xu Z; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin, 150081, China.
  • Sun D; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
  • Zhang W; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province &, Ministry of Health, (23618504), Harbin, 150081, China.
Biol Trace Elem Res ; 2024 Sep 18.
Article en En | MEDLINE | ID: mdl-39292417
ABSTRACT
In recent years, iodine deficiency-related diseases have been effectively controlled; the prevalence of excessive iodine-induced thyroid diseases has increased, such as hyperthyroidism. However, there are still several controversial outcomes regarding the relationship between excessive iodine intakes and hyperthyroidism. MicroRNAs (miRNAs) extensively participate in the progression of thyroid diseases; nevertheless, the relationship and mechanism between iodine exposure and miRNAs have not been explored in hyperthyroidism patients. In this study, a total of 308 pairs of hyperthyroidism patients and healthy controls were enrolled in. Logistic regression analysis showed that level of water iodine >100 µg/L was an independent risk factor for hyperthyroidism. Compared with the healthy control, the serum thyroglobulin (Tg) content and levels of interferon-γ (IFN-γ), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were significantly elevated in hyperthyroidism patients. Further, high-throughput miRNA sequencing was applied to find crucial miRNAs involved in the occurrence of hyperthyroidism related to excessive water iodine. Based on the fold change and Q value, miR-144-3p, miR-204-5p, miR-346, miR-23b-5p, and miR-193b-3p were selected for validation by qRT-PCR. Our results showed that miR-346 and miR-204-5p in the case group were significantly lower than those of the control group, and the similar results found under the level of water iodine >300 µg/L. Nonetheless, no significant difference was found at 10-100 µg/L level of water iodine. Furthermore, the ROC curve indicated that miR-346 and miR-204-5p had the ability to diagnose hyperthyroidism patients. Taken together, excessive water iodine may decrease the expression of miR-346 and miR-204-5p, which mediate the elevation of Tg and cytokines, ultimately making contribution to the development of hyperthyroidism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Trace Elem Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Trace Elem Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos