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Graphitic carbon nitride as a novel anticancer agent: potential mechanisms and efficacy in prostate cancer and glioblastoma treatment.
Yoshihara, Natalia; Lopes, Michelle; Santos, Isabel; Kopke, Beatriz; Almeida, Clara; Araújo, Joyce; Fechine, Pierre B A; Santos-Oliveira, Ralph; Sant'Anna, Celso.
Afiliación
  • Yoshihara N; National Institute of Metrology, Quality and Technology, Eukaryotic Cell Biology Laboratory, Duque de Caxias-RJ, 24250020, Brazil. cbfilho@inmetro.gov.br.
  • Lopes M; National Institute of Metrology, Quality and Technology, Eukaryotic Cell Biology Laboratory, Duque de Caxias-RJ, 24250020, Brazil. cbfilho@inmetro.gov.br.
  • Santos I; National Institute of Metrology, Quality and Technology, Eukaryotic Cell Biology Laboratory, Duque de Caxias-RJ, 24250020, Brazil. cbfilho@inmetro.gov.br.
  • Kopke B; National Institute of Metrology, Quality and Technology, Eukaryotic Cell Biology Laboratory, Duque de Caxias-RJ, 24250020, Brazil. cbfilho@inmetro.gov.br.
  • Almeida C; National Institute of Metrology, Quality and Technology, Laboratory of Microscopy Dimat, Duque de Caxias-RJ, 24250020, Brazil.
  • Araújo J; National Institute of Metrology, Quality and Technology, Laboratory of Microscopy Dimat, Duque de Caxias-RJ, 24250020, Brazil.
  • Fechine PBA; Group of Chemistry of Advanced Materials (GQMat)-Department of Analytical Chemistry and Physical-Chemistry, Federal University of Ceará, Fortaleza-CE, 451-970, Brazil.
  • Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New, Brazil.
  • Sant'Anna C; Radiopharmaceuticals, Rio de Janeiro-RJ, 21941906, Brazil.
Biomater Sci ; 2024 Sep 18.
Article en En | MEDLINE | ID: mdl-39292186
ABSTRACT
Carbon-derived compounds are gaining traction in the scientific community because of their unique properties, such as conductivity and strength, and promising innovations in technology and medicine. Graphitic nitride carbon (g-C3N4) stands out among these compounds because of its potential in antitumor therapies. This study aimed to assess g-C3N4's antitumor potential and cytotoxic mechanisms. Prostate cancer (DU-145) and glioblastoma (U87) cell lines were used to evaluate antitumor effects, whereas RAW 264.7 and HFF-1 non-tumor cells were used for selectivity evaluation. The synthesized g-C3N4 particles underwent comprehensive characterization, including the assessment of particle size, morphology, and oxygen content, employing various techniques, such as X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy, and atomic force microscopy. The results indicated that g-C3N4 significantly affected tumor cell proliferation and viability, exhibiting high cytotoxicity within 48 h. In non-tumor cells, minimal effects on proliferation were observed, except for damage to the cell membranes of RAW 264.7 cells. Moreover, g-C3N4 changed the cell morphology and ultrastructure, affecting cell migration in U87 cells and potentially enhancing migration in RAW 264.7 cells. Biochemical assays in Balb/C mice revealed alterations in alanine aminotransferase, aspartate aminotransferase, and amylase levels. In conclusion, g-C3N4 demonstrated promising antitumor effects with minimal toxicity to non-tumor cells, suggesting its potential in neoplasm treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido