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Hepatoprotective activity of medicinal plants, their phytochemistry, and safety concerns: a systematic review.
Gonfa, Yilma Hunde; Bachheti, Archana; Semwal, Prabhakar; Rai, Nishant; Singab, Abdel Nasser; Bachheti, Rakesh Kumar.
Afiliación
  • Gonfa YH; Department of Chemistry, P.O. Box: 19, Ambo University, Ambo, Ethiopia.
  • Bachheti A; Department of Environment Science, Graphic Era Deemed to be University, Dehradun-248002, Uttarakhand, India.
  • Semwal P; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun-248002, Uttarakhand, India.
  • Rai N; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun-248002, Uttarakhand, India.
  • Singab AN; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.
  • Bachheti RK; Center of Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt.
Z Naturforsch C J Biosci ; 2024 Sep 19.
Article en En | MEDLINE | ID: mdl-39291928
ABSTRACT
Medicinal plants and their derivatives represent a promising reservoir of remedies for various ailments. Especially secondary metabolites of these plants, including alkaloids, flavonoids, phenolic compounds, terpenoids, steroids, saponins, tannins, and anthraquinones, play crucial roles in hepatoprotection. Studies have identified several prominent phytoconstituents, such as silymarin, quercetin, luteolin, glycyrrhizin, curcumin, gallic acid, chebulic acid, catechin, aloin, emodin, liquiritin, liquiritigenin, cudraflavone B, and karaviloside, as effective agents for addressing hepatotoxicity. The mechanisms underlying their efficacy include antioxidant, anti-inflammatory, free radical scavenging, and the ability to block oxidative stress, cytokine production, and stabilize liver cell membranes. The application of natural products derived from medicinal plants in treating liver injuries is rooted in their efficacy, cost-effectiveness, and safety profile, contributing to their popularity. Many studies, encompassing in vitro, in vivo, preclinical, and clinical investigations, have demonstrated that the extracts of medicinal plants mitigate chemical-induced liver damage using animal models. However, intensive research efforts regarding the safety, regulatory standard, and quality control issues for using medicinal plants as hepatoprotective agents remain the strong task of scholars. The primary focus of this systematic review is to analyze the current state of the literature regarding treating liver ailments using extracts from medicinal plants, examining their phytochemical composition, and addressing associated safety considerations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Z Naturforsch C J Biosci Año: 2024 Tipo del documento: Article País de afiliación: Etiopia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Z Naturforsch C J Biosci Año: 2024 Tipo del documento: Article País de afiliación: Etiopia Pais de publicación: Alemania