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Efficacy of Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) a Treatment for Cancer-related Cognitive Impairment (CRCI): A Randomized Controlled Trial.
Lengacher, Cecile A; Reich, Richard R; Rodriguez, Carmen S; Nguyen, Anh Thy; Park, Jong Y; Meng, Hongdao; Tinsley, Sara; Hueluer, Gizem; Donovan, Kristine A; Moscoso, Manolete S; Bornstein, Elizabeth; Kiluk, John; Nidamanur, Sreenidhi; Padgett, Lynne S; Lucas, Jean M; Fonseca, Tamela; Joshi, Anisha; Lin, Katherine J; Goodman, Matthew; Kip, Kevin E.
Afiliación
  • Lengacher CA; University of South Florida College of Nursing, Tampa, Florida, USA.
  • Reich RR; Moffitt Cancer Center, Tampa, Florida, USA.
  • Rodriguez CS; University of South Florida College of Nursing, Tampa, Florida, USA.
  • Nguyen AT; University of South Florida College of Nursing, Tampa, Florida, USA.
  • Park JY; Moffitt Cancer Center, Tampa, Florida, USA.
  • Meng H; University of South Florida College of Behavioral and Community Sciences, Tampa, Florida, USA.
  • Tinsley S; Moffitt Cancer Center, Tampa, Florida, USA.
  • Hueluer G; University of Bonn, Bonn, Germany.
  • Donovan KA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  • Moscoso MS; University of South Florida College of Nursing, Tampa, Florida, USA.
  • Bornstein E; Brian D. Jellison Cancer Institute, Sarasota, Florida, USA.
  • Kiluk J; Moffitt Cancer Center, Tampa, Florida, USA.
  • Nidamanur S; University of South Florida College of Arts and Sciences, Tampa, Florida, USA.
  • Padgett LS; Veteran Affairs Office of Research & Development, Washington, Washington DC, USA.
  • Lucas JM; Sarasota Memorial Health Care System, Sarasota, Florida, USA.
  • Fonseca T; Sarasota Memorial Health Care System, Sarasota, Florida, USA.
  • Joshi A; University of South Florida College of Nursing, Tampa, Florida, USA.
  • Lin KJ; University of South Florida College of Nursing, Tampa, Florida, USA.
  • Goodman M; University of Virginia School of Medicine, Charlottesville, Virgina, USA.
  • Kip KE; UPMC Health Services Division, Pittsburgh, Pennsylvania, USA.
J Integr Complement Med ; 2024 Sep 18.
Article en En | MEDLINE | ID: mdl-39291332
ABSTRACT

Introduction:

The Mindfulness-Based Stress Reduction (MBSR) Program for breast cancer survivors (BCS) is designed to enhance cognitive training through formal and informal meditational practices. This randomized clinical trial (RCT) aimed to evaluate if BCS assigned to either the MBSR(BC), Breast Cancer Education Support (BCES), or Usual Care (UC) regimens experienced greater improvements at 6, 12, and 26 weeks on objective and subjective cognitive performance.

Methods:

BCS (n = 212) randomized to a three-group RCT MBSR(BC) (n = 91), BCES (n = 90), or UC (n = 31) were assessed on cognitive performance and symptoms at baseline, 6, 12, and 26 weeks. Linear mixed models were fit to evaluate the effects of the MBSR(BC) program, hypothesizing ordered effect improvements (MBSR[BC] highest, BCES intermediate, UC lowest) along with baseline characteristics evaluated as moderators.

Results:

Of the BCS (mean age of 57), 73% were White, and non-Hispanic, and 77% received both chemotherapy (CT) and radiation. Cognitive performance improved in all groups. Although there were no statistically significant between-group differences in cognitive outcomes, significant symptom reductions occurred for the MBSR(BC) group (p = 0.003). Within-group effect size analysis at 26 weeks showed substantial improvements in all three groups (effect sizes >0.50) in subjective impairments and quality of life (effect size >0.50) and objective measures of cognitive performance. MBSR(BC) showed the largest within-group effect size in the reduction of fatigue (effect size = 0.81). Effect sizes occurred in the hypothesized direction for 10 of the 18 outcomes.

Discussion:

Although the MBSR(BC) program did not show significant differences in cognitive performance compared with BCES and UC, all groups improved and reductions in fatigue were beneficial for MBSR(BC). Results suggest that cognitive performance may improve after CT over time considering one's natural history. Furthermore, BCS enrolled in RCTs may be more motivated to improve their health status (NCT02786797).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Integr Complement Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Integr Complement Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos