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The impact of faecal diversion on the gut microbiome: a systematic review.
Sam, Shien Wenn; Hafeez, Bilal; Ong, Hwa Ian; Gill, Sonia; Smibert, Olivia; Lavelle, Aonghus; Burgess, Adele; Proud, David; Mohan, Helen.
Afiliación
  • Sam SW; Faculty of Medical and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
  • Hafeez B; Department of Surgery, Austin Health Department of Surgery, Heidelberg, VIC, Australia.
  • Ong HI; Faculty of Medical and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
  • Gill S; Department of Surgery, Austin Health Department of Surgery, Heidelberg, VIC, Australia.
  • Smibert O; Faculty of Medical and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
  • Lavelle A; Department of Surgery, Austin Health Department of Surgery, Heidelberg, VIC, Australia.
  • Burgess A; Faculty of Medical and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
  • Proud D; Department of Surgery, Austin Health Department of Surgery, Heidelberg, VIC, Australia.
  • Mohan H; Faculty of Medical and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
Gut Microbiome (Camb) ; 5: e4, 2024.
Article en En | MEDLINE | ID: mdl-39290660
ABSTRACT
Diversion of the faecal stream is associated with diversion colitis (DC). Preliminary studies indicate that microbiome dysbiosis contributes to its development and potentially treatment. This review aims to characterise these changes in the context of faecal diversion and identify their clinical impact. A systematic search was conducted using MEDLINE, EMBASE and CENTRAL databases using a predefined search strategy identifying studies investigating changes in microbiome following diversion. Findings reported according to PRISMA guidelines. Of 743 results, 6 met inclusion criteria. Five reported significantly decreased microbiome diversity in the diverted colon. At phylum level, decreases in Bacillota with a concomitant increase in Pseudomonadota were observed, consistent with dysbiosis. At genus level, studies reported decreases in beneficial lactic acid bacteria which produce short-chain fatty acid (SCFA), which inversely correlated with disease severity. Significant losses in commensals were also noted. These changes were seen to be partially reversible with restoration of bowel continuity. Changes within the microbiome were reflected by histopathological findings suggestive of intestinal dysfunction. Faecal diversion is associated with dysbiosis in the diverted colon which may have clinical implications. This is reflected in loss of microbiome diversity, increases in potentially pathogenic-associated phyla and reduction in SCFA-producing and commensal bacteria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gut Microbiome (Camb) Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gut Microbiome (Camb) Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido