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Microneedles mediated-dermal delivery of Vitamin C: Formulation, characterization, cytotoxicity, and enhancement of stability.
Hamed, Rania; AbuKwiak, Amani D; Aburayya, Rafa; Alkilani, Ahlam Zaid; Hamadneh, Lama; Naser, Mais; Al-Adhami, Yasmeen; Alhusban, Ala A.
Afiliación
  • Hamed R; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Jordan, Amman, 11733, Jordan.
  • AbuKwiak AD; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Jordan, Amman, 11733, Jordan.
  • Aburayya R; Department of Pharmacy, Faculty of Pharmacy, Zarqa University, Zarqa, Zarqa, 13110, Jordan.
  • Alkilani AZ; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Jordan, Amman, 11733, Jordan.
  • Hamadneh L; Department of Pharmacy, Faculty of Pharmacy, Zarqa University, Zarqa, Zarqa, 13110, Jordan.
  • Naser M; Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, P.O. Box 206, Al-Salt, 19117, Jordan.
  • Al-Adhami Y; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Jordan, Amman, 11733, Jordan.
  • Alhusban AA; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Jordan, Amman, 11733, Jordan.
Heliyon ; 10(17): e37381, 2024 Sep 15.
Article en En | MEDLINE | ID: mdl-39290271
ABSTRACT
Vitamin C (VIT C) is an antioxidant that prevents skin aging. Although dermal delivery is one of the most effective routes to transport VIT C to the skin, the impact of this route can be limited by the barrier function of the stratum corneum (SC). Additionally, VIT C rapidly oxidized and degraded under light and temperature. Therefore, this study provides an approach to utilizing microneedles (MNs) to improve the dermal delivery of VIT C and enhance its stability by incorporating a stabilizing system of ethylenediaminetetraacetic acid (EDTA) and sodium metabisulfite (Meta) within the MNs. Vitamin C microneedles (VIT C MNs) were fabricated using different biodegradable polymers and various concentrations of EDTA/Meta. VIT C MNs were evaluated for morphology, VIT C content, mechanical properties, dissolution rate, needles' insertion, physicochemical properties, ex vivo permeation, viscosity of VIT C polymeric solutions, cytotoxicity, and stability. The results showed that VIT C MNs were uniform and mechanically strong. The recovery of VIT C in MNs was 88.3-90.0 %. The dissolution rate of MNs was <30 min. The flux of VIT C varied based on the composition of MNs. VIT C MNs demonstrated safety against human dermal fibroblasts. VIT C MNs with EDTA/Meta (0.1/0.3 %) were stable under different storage conditions for two months. In conclusion, VIT C MNs were successfully developed using biodegradable polymers, and the stabilizing system (EDTA/META) provided a stable dermal delivery system for VIT C to protect skin from aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Reino Unido