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Incidence of Infective Endocarditis Post-TPVR with MELODY Valve in Pediatric Patients: A Systematic Review and Meta-Analysis.
Veldurthy, Sruthi; Shrivastava, Deepali; Majeed, Farhat; Ayaz, Tooba; Munir, Aqssa; Haider, Ali; Mylavarapu, Maneeth.
Afiliación
  • Veldurthy S; Department of Pediatrics, Mediciti Institute of Medical Sciences, Telangana, India.
  • Shrivastava D; Department of Anesthesia, University of Minnesota, Minneapolis, USA.
  • Majeed F; Department of Medicine, Pakistan Medical and Dental Council, Islamabad, Pakistan.
  • Ayaz T; Department of Medicine, Baqai Medical University, Karachi, Pakistan.
  • Munir A; Department of Anesthesia, Mayo Hospital, Lahore, Pakistan.
  • Haider A; Department of Allied Health Sciences, The University of Lahore, Gujrat, Pakistan.
  • Mylavarapu M; Department of Public Health, Adelphi University, NY, USA.
Curr Cardiol Rev ; 2024 Sep 16.
Article en En | MEDLINE | ID: mdl-39289937
ABSTRACT

INTRODUCTION:

Infective Endocarditis (IE) has emerged to be one of the most impactful adverse complications post-transcatheter procedures, especially Transcatheter Pulmonary Valve Replacement (TPVR). We conducted a systematic review and meta-analysis with the aim of identifying the incidence of IE post-TPVR with the MELODY valve in the pediatric population.

METHODS:

A comprehensive literature search was performed across several prominent databases, including PubMed/MEDLINE, SCOPUS, and Science Direct. Studies compared the clinical outcomes of pediatric patients who received TPVR using the MELODY valve. Data extraction was done for variables like the total pediatric patient population that underwent TPVR with MELODY valve, mean age, the sex of the patients, the incidence rate of IE following the procedure, and the duration between the procedure and the occurrence of IE. Inverse Variance was used to estimate the incidence of IE in patients who underwent TPVR with respective 95% confidence interval (CI).

RESULTS:

In total, 4 studies with 414 pediatric patients who underwent TPVR using the MELODY valve were included in the study. The mean age of the study population was 12.7 ± 3.11 years. The pooled incidence of IE following TPVR with MELODY valve in the pediatric population was 17.70% (95% Cl 3.84-31.55; p<0.00001). Additionally, the mean length of duration to develop IE following TPVR with MELODY valve in the pediatric population was 2.18 years (95% Cl 0.35-4.01; p<0.00001).

CONCLUSION:

Our meta-analysis reveals that IE post-TPVR with MELODY valve in pediatric patients is a significant complication, clinically and statistically. Further research needs to be done to understand the risk factors and develop better management strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Cardiol Rev Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Cardiol Rev Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Emiratos Árabes Unidos