Recent Advances in the Linkers of Drug Conjugates.

Deng, Shirui; Wen, Xiaoan; Wang, Jinzheng

Deng, Shirui; Wen, Xiaoan; Wang, Jinzheng.

Afiliación

Deng S; School of China Pharmaceutical University, Nanjing, China.
Wen X; School of China Pharmaceutical University, Nanjing, China.
Wang J; Department of Lingang Laboratory, Shanghai, China.

Curr Med Chem ; 2024 Sep 16.

Article en En | MEDLINE | ID: mdl-39289930

ABSTRACT

ABSTRACT

Drug conjugates have emerged as a pivotal research focus in the field of targeted cancer therapy. They represent a widely explored prodrug strategy that significantly enhances the therapeutic index of drugs while minimizing side effects. The stability and selective cleavage of the linker within drug conjugates are critical for the therapeutic efficacy and targeted treatment achieved by these conjugates. In this review, we have categorized the linkers based on their cleavage mode and summarized the chemical properties, advantages, and limitations of various types of cleavable linkers. Particularly, examples have been provided to illustrate their specific potential for development.

Palabras clave

Linkers; antibody-drug conjugates; cleavable linkers; non-cleavable linkers; peptide-drug conjugates; targeted therapy.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Med Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Emiratos Árabes Unidos

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