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Ameliorative effects of silymarin on aflatoxin B1 toxicity in weaned rabbits: impact on growth, blood profile, and oxidative stress.
Imbabi, Tharwat A; El-Sayed, Abdelkarim I; El-Habbak, Mohamed H; Nasr, Mohammed A; Halawa, Eman H.
Afiliación
  • Imbabi TA; Department of Animal Production, Faculty of Agriculture, Benha University, Benha, Egypt.
  • El-Sayed AI; Department of Animal Production, Faculty of Agriculture, Benha University, Benha, Egypt.
  • El-Habbak MH; Department of Plant Pathology, Faculty of Agriculture, Benha University, Benha, Egypt.
  • Nasr MA; Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt. mohammed.nasr@zu.edu.eg.
  • Halawa EH; Department of Animal Production, Faculty of Agriculture, Benha University, Benha, Egypt.
Sci Rep ; 14(1): 21666, 2024 09 17.
Article en En | MEDLINE | ID: mdl-39289432
ABSTRACT
Natural plant extracts offer numerous health benefits for rabbits, including improved feed utilization, antimycotic and antiaflatoxigenic effect, antioxidants, immunological modulation, and growth performance. The aim of the current study was to investigate the effects of silymarin on the performance, hemato-biochemical indices, antioxidants, and villus morphology. A total of 45 Moshtohor 4 weeks old weaned male rabbits were randomly allocated into three groups (15 rabbit/each) each group with 5 replicates. The first group served as the control group feed on an infected diet by aflatoxin B1 (AFB1) 0.02 mg/kg BW, while the second and third groups received an infected diet by AFB1 (0.02 mg/kg BW) and was treated with Silymarin 20 mg/kg BW/day or 30 mg/kg BW/day, respectively. Regarding the growth performance, silymarin supplementation significantly improved the final body weight compared with the control group. Physiologically, silymarin induced high level of dose-dependent total red blood cell count, hematocrit, eosinophils, high-density lipoprotein cholesterol, superoxid dismutase, catalase activity, total antioxidant capacityand intestinal villi width and length. Moreover, silymarin significantly restricted oxidative stress indicators, malondialdehyde, Alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglyceridein rabbits treated with (AFB1). In conclusion, silymarin supplementation to AFB1 contaminated rabbit diet may mitigate the negative effect of AFB1 on the rabbit performance and health status and increase growth performance, average daily gain, immunological modulation and antioxidants and provide a theoretical basis for the application of silymarin in livestock production.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silimarina / Destete / Aflatoxina B1 / Estrés Oxidativo / Antioxidantes Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silimarina / Destete / Aflatoxina B1 / Estrés Oxidativo / Antioxidantes Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido