Your browser doesn't support javascript.
loading
Vascular mimicry and mosaic vessels in parathyroid tumours: a new diagnostic approach?
Falleni, Monica; Dal Lago, Matteo; Tosi, Delfina; Ghilardi, Giorgio; De Pasquale, Loredana; Saibene, Alberto M; Felisati, Giovanni; Cozzolino, Mario; Gianelli, Umberto.
Afiliación
  • Falleni M; Unit of Pathology, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milano, Italy.
  • Dal Lago M; Unit of Pathology, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milano, Italy.
  • Tosi D; Unit of Pathology, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milano, Italy delfina.tosi@unimi.it.
  • Ghilardi G; Surgical Unit, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milano, Italy.
  • De Pasquale L; U.O.S. Thyroid Unit, ASST Santi Paolo e Carlo, Milano, Italy.
  • Saibene AM; Otolaryngology Unit, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milano, Italy.
  • Felisati G; Otolaryngology Unit, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milano, Italy.
  • Cozzolino M; Renal Division, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milano, Italy.
  • Gianelli U; Unit of Pathology, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milano, Italy.
J Clin Pathol ; 2024 Sep 17.
Article en En | MEDLINE | ID: mdl-39288990
ABSTRACT

AIMS:

Evaluation of 'alternative' vascularisation in human cancer is considered an important prognostic parameter; the 2022 WHO classification of parathyroid tumours despite progresses in clinical triaging of patients strongly emphasises new histopathological parameters to properly stratify these lesions. 'Alternative' and 'classic' vessels were here investigated for the first time in parathyroid tumours for their possible histopathological and clinical relevance during progression.

METHODS:

Using a double CD31/PAS staining, microvessel density (MVD, 'classic' CD31+ vessels), mosaic vessel density (MoVD, 'alternative' CD31+/-vessels) and vessel mimicry density (VMD, 'alternative' CD31-/PAS+ vessels) were evaluated in 4 normal parathyroid glands (N), 50 Adenomas (A), 35 Atypical Tumours (AT) and 10 Carcinomas (K).

RESULTS:

Compared with N, MVD significantly increased in A (p=0.012) and decreased in K (p=0.013) with vessel counts lower than in AT and A (p<0.001). MoVs and VMs, absent in normal tissue, were documented in non-benign parathyroid lesions (AT, K) (p<0.001), with MoVs and VMs most represented in AT and K, respectively (p<0.001), in peripheral growing areas. Vessel distribution was correlated to neoplastic progression (r=-0.541 MVD; r=+0.760 MoVD, r=+0.733 VMD), with MVD decrease in AT and K inversely related to MoVD and VMD increase (r=-0.503 and r=-0.456).

CONCLUSIONS:

'Alternative' vessel identification in parathyroid tumours is crucial because it (1) explains the paradox of non-angiogenic tumours, consisting in a new bloody non-endothelial vessel network and (2) helps pathologists to unmask worrisome lesions. Furthermore, detection of alternative vascular systems in human tumours might explain the limited success of antiangiogenic therapies and encourage new oncological studies.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Pathol Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Pathol Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido