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Validation of novel risk prediction models in patients with Brugada syndrome: A multicenter study in Japan.
Kamakura, Tsukasa; Takagi, Masahiko; Komatsu, Yuki; Shinohara, Tetsuji; Aizawa, Yoshiyasu; Sekiguchi, Yukio; Yokoyama, Yasuhiro; Aihara, Naohiko; Hiraoka, Masayasu; Aonuma, Kazutaka.
Afiliación
  • Kamakura T; Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address: tsukasa@ncvc.go.jp.
  • Takagi M; Department of Medicine II, Kansai Medical University, Moriguchi, Japan.
  • Komatsu Y; Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Shinohara T; Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Oita, Japan.
  • Aizawa Y; Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.
  • Sekiguchi Y; Department of Cardiovascular Internal Medicine, Sakakibara Heart Institute, Fuchu, Japan.
  • Yokoyama Y; Department of Internal Medicine, Division of Cardiology, Yamato Tokushukai Hospital, Kanagawa, Japan.
  • Aihara N; Department of Internal Medicine, Senri Central Hospital, Suita, Japan.
  • Hiraoka M; Department of Cardiology, Tokyo Medical and Dental University, Tokyo, Japan.
  • Aonuma K; Department of Cardiology, Saiseikai Mito Hospital, Mito, Japan.
Heart Rhythm ; 2024 Sep 15.
Article en En | MEDLINE | ID: mdl-39288881
ABSTRACT

BACKGROUND:

Risk stratification in patients with Brugada syndrome (BrS) is challenging, especially in those at intermediate risk. The Predicting Arrhythmic evenT (PAT) score has recently been demonstrated to be excellent for predicting future arrhythmic events in patients without prior ventricular fibrillation (VF). However, validation studies are lacking.

OBJECTIVE:

This study aimed to assess the performance of a novel risk stratification model in predicting future VF events in patients with BrS in a Japanese multicenter cohort.

METHODS:

The PAT score was calculated for 413 patients with BrS (mean age, 50.9 ± 13.6 years; 395 men) from 59 hospitals in Japan, including 314 patients without prior VF. The incidence of developing VF during the follow-up period was investigated.

RESULTS:

During the 106.8-month follow-up period, 54 patients (13.1%) experienced VF events. Of the 314 patients without prior VF at enrollment, 14 (4.5%) experienced VF events. The incidence of VF events during the follow-up period was significantly higher in patients with PAT scores ≥ 10 than in those with scores < 10 (41/173 [23.7%] vs 13/240 [5.4%]; P < .0001) in the total cohort. No difference was observed in the incidence of VF events between patients with PAT scores ≥ 10 and < 10 among the 314 patients without prior VF (6/86 [7.0%] vs 8/228 [3.5%]; P = .22). PAT scores ≥ 10 predicted future VF events with a sensitivity and specificity of 42.9% and 73.3%, respectively.

CONCLUSION:

This Japanese multicenter registry demonstrated that the novel risk stratification model could not accurately predict future VF events in patients with BrS but without prior VF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heart Rhythm Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heart Rhythm Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos