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Air pollution exposure, chemical compositions, and risk of expiratory airflow limitation in youth in Northeast China.
Gao, Jing; Zhang, Xiangsu; Ding, Huiyuan; Bao, Yijing; Zhang, Chuyang; Chi, Baofeng; Xia, Yang; Zhao, Yuhong; Zhang, Hehua.
Afiliación
  • Gao J; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, China.
  • Zhang X; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Graduate School of China Medical University, Shenyang, China.
  • Ding H; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, China.
  • Bao Y; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, China.
  • Zhang C; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, China.
  • Chi B; Inner Mongolia Medical University, Inner Mongolia, China.
  • Xia Y; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, China.
  • Zhao Y; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, China. Electronic address: yhzhaosj_hospital@126.com.
  • Zhang H; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, China; Clinical Trials and Translation Center, Shengjing Hospital of China Medical University, Shenyang, Chi
Ecotoxicol Environ Saf ; 285: 117055, 2024 Oct 15.
Article en En | MEDLINE | ID: mdl-39288734
ABSTRACT

BACKGROUND:

Expiratory airflow limitation (EAL) is closely associated with respiratory health in youth and adulthood. Owing to limited evidence, we aim to estimate the association between air pollutants, both individually and in combination, along with their chemical compositions, and the risk of EAL in youth based on data obtained from Northeast China Biobank.

METHODS:

Pulmonary function was evaluated using a medical-grade pulmonary function analyzer, with EAL defined as a forced expiratory flow in 1 s/ forced vital capacity ratio of < 0.8. Land use regression models were used to predict exposure to six air pollutants. Air pollution score (APS) for each participant was constructed as combined exposure. The chemical composition of particulate matter with an aerodynamic diameter of ≤ 2.5 µm (PM2.5) was determined using a validated machine-learning algorithm. Logistic regression models were employed to estimate effect sizes, and odds ratio (OR) and 95 % confidence intervals (CI) were calculated.

RESULTS:

In total, 905 EAL cases were identified among the 4301 participants, with a prevalence of 21.04 %. Each inter-quartile range increase in APS was associated with a 25 % higher risk of EAL (OR = 1.25, 95 % CI 1.12, 1.39). Among the pollutants analyzed, PM2.5 exposure had the strongest association with the risk of EAL (OR = 1.33, 95 % CI 1.18, 1.52). Out of the five chemical components, sulfate (SO2-4) (OR = 1.39, 95 % CI 1.24, 1.57) and ammonium (NH+4) (OR = 1.39, 95 % CI 1.23, 1.57) exhibited the strongest associations with the risk of EAL.

CONCLUSIONS:

Overall, combined effects of air pollution increased the risk of EAL in youth, with SO2-4 and NH+4 emerging as the predominant contributing chemical components in Northeast China.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Atmosféricos / Contaminación del Aire / Exposición a Riesgos Ambientales / Material Particulado Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Ecotoxicol Environ Saf Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Atmosféricos / Contaminación del Aire / Exposición a Riesgos Ambientales / Material Particulado Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Ecotoxicol Environ Saf Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos