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Natural agents derived Pickering emulsion enabled by silica nanoparticles with enhanced antibacterial activity against drug-resistant bacteria.
Yao, Yining; Feng, Jiayou; Ao, Niqi; Zhang, Ye; Zhang, Jun; Wang, Yue; Liu, Chao; Wang, Meiyan; Yu, Chengzhong.
Afiliación
  • Yao Y; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
  • Feng J; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
  • Ao N; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
  • Zhang Y; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
  • Zhang J; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
  • Wang Y; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
  • Liu C; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China. Electronic address: cliu@chem.ecnu.edu.cn.
  • Wang M; School of Medicine, Shanghai University, Shanghai 200444, China. Electronic address: wangmy@shu.edu.cn.
  • Yu C; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia. Electronic address: c.yu@uq.edu.au.
J Colloid Interface Sci ; 678(Pt B): 1158-1168, 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39288711
ABSTRACT
The emergence of antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) has become a global health challenge due to the overuse of antibiotics. Natural substances including enzymes and essential oils have shown great potential as alternative treatment options. However, the combinational use of these natural agents remains challenging due to the denaturation of enzymes upon direct contact with oil. In this study, we report the design of a Pickering emulsion containing two natural antibacterial agents, lysozyme and tea tree oil, stabilized by fractal silica nanoparticles. In this design, the enzyme activity is kept and the volatility problem of tea tree oil is mitigated. Due to synergistic bacterial cell wall digestion and membrane disruption functions, potent bactericidal efficacy in vitro against drug-resistant bacteria is achieved. The therapeutic potential is further demonstrated in a wound healing model with drug-resistant bacteria infection, better than a synthetic antibiotic, Ampicillin. This study opens new avenues for the development of natural product-based antimicrobial treatments with promising application potential.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Colloid Interface Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Colloid Interface Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos