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Association between non-neoplastic bladder diseases and bladder cancer risk: insights from Mendelian randomization studies.
Zhang, Yi; Li, Rongkang; Zhang, Shaohua; Li, Hangxu.
Afiliación
  • Zhang Y; Department of Urology, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, No. 2 Heping Road, Section 5, Linghe District, Jinzhou, 121001, Liaoning, China.
  • Li R; Department of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, No. 2 Renmin Street, Section 5, Guta District, Jinzhou, 121002, Liaoning, China.
  • Zhang S; Motor Robotics Institute (MRI), South China Hospital, Health Science Center, Shenzhen University, No. 1 Fuxin Road, Longgang District, Shenzhen, Guangdong, 518100, China.
  • Li H; Motor Robotics Institute (MRI), South China Hospital, Health Science Center, Shenzhen University, No. 1 Fuxin Road, Longgang District, Shenzhen, Guangdong, 518100, China.
Postgrad Med J ; 2024 Sep 17.
Article en En | MEDLINE | ID: mdl-39287940
ABSTRACT

PURPOSE:

Our aim is to explore the relation between non-neoplastic bladder diseases and bladder cancer (BC) from a genetic level utilizing Mendelian randomization (MR).

METHODS:

Single nucleotide polymorphisms (SNPs) related to cystitis, bladder stones, and neuropathic bladder were gathered from the IEU genome-wide association studies database. Quality control on SNPs was performed via stringent screening criteria. The relation between non-neoplastic bladder diseases and BC risk was evaluated using inverse-variance weighted, MR-Egger, weighted median, simple mode, and weighted mode methods. Cochran's Q test was conducted to assess the heterogeneity of SNPs; in addition, the MR-Egger intercept test was employed to examine the horizontal pleiotropy of SNPs. Exposure and outcomes were validated using a validation database. Finally, BC was used as the exposure and non-neoplastic bladder diseases as the outcome to evaluate reverse causality.

RESULTS:

The outcomes showcased that genetically predicted cystitis is significantly correlated to a raised risk of BC (inverse-variance weighted odds ratio [95%] = 1.1737 [1.0317, 1.3352], P = .0149), consistent with the BC validation cohort in the MR analysis. Nevertheless, no causal relation was found between bladder stone and neuropathic bladder with BC risk (P > .05). In this study, sensitivity analysis indicated no heterogeneity or horizontal pleiotropy.

CONCLUSION:

The study presents proof of a genetic-level causal relation between cystitis and increased BC risk, while bladder stones and neuropathic bladder do not show similar associations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Postgrad Med J Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Postgrad Med J Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido