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Bilayer MOF nanomachine for precision breast cancer cell fluorescent imaging and therapy.
Zhao, Yijun; Hu, Guizhen; Li, Zhaoge; Nie, Yamin; Li, Yonghong; Zhou, Yanmei.
Afiliación
  • Zhao Y; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
  • Hu G; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
  • Li Z; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
  • Nie Y; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
  • Li Y; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
  • Zhou Y; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China. zhouyanmei@henu.edu.cn.
Mikrochim Acta ; 191(10): 606, 2024 09 17.
Article en En | MEDLINE | ID: mdl-39287790
ABSTRACT
A bilayer MOF reporter (ZIF-67@FAM-mRNA@ZIF-8) was synthesized, and the ZIF-67 was used as a carrier and fluorescent quencher to connect the FAM reporter through electrostatic adsorption and coordination effect. The ZIF-8 covering the outer layer can improve the stability of the probe and cell permeability, which helps the FAM reporter effectively release. After entering the cancer cells, the acidic environment in the cells induced the decomposition of ZIF-8. The excess ATP in the tumor cells competitively binds ZIF-67, causing the FAM reporter to shed and restore fluorescence. The shed FAM reporter was specifically bound to the overexpressed miRNA-21 in breast cancer cells to achieve fluorescence imaging and therapy of breast cancer. The results of specific imaging and apoptosis experiments of breast cancer cells indicate that bilayer MOF nanomachine provides an effective nanotherapy platform for accurate fluorescence imaging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / MicroARNs / Imagen Óptica / Colorantes Fluorescentes / Estructuras Metalorgánicas Límite: Female / Humans Idioma: En Revista: Mikrochim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / MicroARNs / Imagen Óptica / Colorantes Fluorescentes / Estructuras Metalorgánicas Límite: Female / Humans Idioma: En Revista: Mikrochim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria