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INTEREST OF REGULAR ASSAYS OF AQUEOUS HUMOR INTERLEUKIN-10 LEVELS IN MONITORING OF VITREORETINAL LYMPHOMA.
Metayer, Charline; Kodjikian, Laurent; Nguyen, Anh-Minh; Loria, Olivier; Chaperon, Mayeul; Ghesquieres, Hervé; Mathis, Thibaud.
Afiliación
  • Metayer C; Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
  • Kodjikian L; Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
  • Nguyen AM; Laboratoire UMR-CNRS 5510 MATEIS, INSA, Université Lyon 1, Villeurbanne, France.
  • Loria O; Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
  • Chaperon M; Centre Ophtalmologique Pôle Vision, Clinique du Val d'Ouest, Ecully, France; and.
  • Ghesquieres H; Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
  • Mathis T; Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
Retina ; 44(10): 1807-1813, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-39287544
ABSTRACT

PURPOSE:

To investigate the variation of interleukin-10 (IL-10) levels in the aqueous humor (AH) of patients with vitreoretinal lymphoma (VRL) throughout therapy and follow-up and analyze the relation of these variations with VRL clinical course and relapse.

METHODS:

This study retrospectively included consecutive patients diagnosed with VRL in a single center. AH IL-10 samples and patient clinical course were evaluated. The response to treatment was evaluated according to the criteria set by the International Primary Central Nervous System Lymphoma Collaborative Group.

RESULTS:

A total of 59 eyes of 34 patients were included. Interleukin-10 levels decreased significantly at first AH sample after therapy induction (median [IQR] 3.0 [2.8-3.6] months) among patients in complete clinical remission (P < 0.001). Among patients in complete clinical remission with residual detectable IL-10 in AH after therapy induction (85.3% systemic chemotherapy, 11.8% intravitreal methotrexate, 2.9% palliative care), 87.5% experienced ocular relapse within 5 years. The detection of IL-10 in AH at the first visit after induction for complete clinical remission obtained a sensitivity of 77.8% (95% CI 0.45-0.96) and a specificity of 96.4% (95% CI 0.82-0.99) to predict ocular relapse. For relapsing eyes (N = 26), IL-10 significantly increased between the last IL-10 measurement and the time of the first ocular relapse (P < 0.001). In 76.0% of cases, an increase in IL-10 was detected earlier than clinical relapse with a mean (SD) of 4.0 (2.4) months.

CONCLUSION:

The present study suggested the usefulness of IL-10 in the prognosis of VRL. This study showed a relation between IL-10 in AH and tumoral activity, and for the first time with disease relapse.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Humor Acuoso / Cuerpo Vítreo / Interleucina-10 / Neoplasias de la Retina Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Retina Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Humor Acuoso / Cuerpo Vítreo / Interleucina-10 / Neoplasias de la Retina Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Retina Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos